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請使用永久網址來引用或連結此文件:
https://nccur.lib.nccu.edu.tw/handle/140.119/79419
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| 題名: | Reduced Gut Acidity Induces an Obese-Like Phenotype in Drosophila melanogaster and in Mice |
| 作者: | Lin, Wei-Sheng;Huang, Cheng-Wen;Song, You-Sheng;Yen, Jui-Hung;Kuo, Ping-Chang;Yeh, Sheng-Rong;Lin, Hung-Yu;Fu, Tsai-Feng;Wu, Ming-Shiang;Wang, Horng-Dar;Wang, Pei-Yu
江振東 |
| 貢獻者: | 統計系 |
| 日期: | 2015-10 |
| 上傳時間: | 2015-11-25 16:35:57 (UTC+8) |
| 摘要: | In order to identify genes involved in stress and metabolic regulation, we carried out a Drosophila P-element-mediated mutagenesis screen for starvation resistance. We isolated a mutant, m2, that showed a 23% increase in survival time under starvation conditions. The P-element insertion was mapped to the region upstream of the vha16-1 gene, which encodes the c subunit of the vacuolar-type H+-ATPase. We found that vha16-1 is highly expressed in the fly midgut, and that m2 mutant flies are hypomorphic for vha16-1 and also exhibit reduced midgut acidity. This deficit is likely to induce altered metabolism and contribute to accelerated aging, since vha16-1 mutant flies are short-lived and display increases in body weight and lipid accumulation. Similar phenotypes were also induced by pharmacological treatment, through feeding normal flies and mice with a carbonic anhydrase inhibitor (acetazolamide) or proton pump inhibitor (PPI, lansoprazole) to suppress gut acid production. Our study may thus provide a useful model for investigating chronic acid suppression in patients. |
| 關聯: | PLoS One, 10(10), e0139722 |
| 資料類型: | article |
| DOI 連結: | http://dx.doi.org/10.1371/journal.pone.0139722 |
| DOI: | 10.1371/journal.pone.0139722 |
| 顯示於類別: | [統計學系] 期刊論文
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| e0139722.pdf | | 1142Kb | Adobe PDF2 | 845 | 檢視/開啟 |
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