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題名:	Two-stage analysis for gene-environment interaction utilizing both case-only and family-based analysis
作者:	程毅豪;林惠文;劉惠美 Chen, Yi-Hau;Lin, Hui-Wen;Liu, Huimei
貢獻者:	政大統計系
關鍵詞:	case-parent studies;case-sibling studies;gene-environment independence;parental missingness
日期:	2009-02
上傳時間:	2013-12-12 18:09:16 (UTC+8)
摘要:	The case-only study and family-based study are two popular study designs for detecting gene-environment interactions. It is well known that the case-only analysis is efficient, but its validity relies crucially on the assumption of gene-environment independence in the study population. In contrast, the family-based analysis is robust to the violation of such an assumption, but is less efficient. We propose a two-stage study design for detecting gene-environment interactions, where a case-only study is performed at the first stage, and a case-parent/case-sibling study is performed at the second stage on a random subsample of the first-stage case sample as well as their parents/unaffected siblings. Statistical inference procedures are developed for the proposed two-stage study designs, which not only preserve the robustness property of the family-based analysis, but also utilize information from the case-only analysis to enhance estimation efficiency and testing power. Simulation results reveal both the robustness and efficiency of the proposed strategies. Genet. Epidemiol. 2008. © 2008 Wiley-Liss, Inc.
關聯:	Genet Epidemiol, 33(2), 95-104
資料類型:	article
DOI 連結:	http://dx.doi.org/10.1002/gepi.20357
DOI:	10.1002/gepi.20357
顯示於類別:	[統計學系] 期刊論文

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