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政大機構典藏 > 商學院 > 統計學系 > 期刊論文 > Item 140.119/62434

Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/62434

Title:	The Dynamic Model for Cancer Relapse Based on Two-stage Model of Carcinogenesis
Authors:	高立箴;陳麗霞 Kao, Lie-Jane;Chen, Li-Shya
Contributors:	政大統計系
Keywords:	Cancer relapse;Chemotherapy randomization;Cure rate;Observable malignant clone;Poisson cluster process;Two-stage carcinogenesis model
Date:	2012-04
Issue Date:	2013-12-12 18:02:59 (UTC+8)
Abstract:	In this article, the time from the start of chemotherapy randomization until cancer relapse is of primary interest. Here, cancer relapse refers to the appearance of the first observable malignant clone after therapy. A dynamic model for cancer relapse after chemotherapy is developed. The model differs from the traditional cure rate models in that it takes into consideration the growth kinetics of malignant tumors using a two-stage carcinogenesis model. The survival and hazard functions for cancer relapse time are derived, and a simulation study is performed to validate the underlying model.
Relation:	Communications in Statistics--Theorey and Methods, 41(10), 1701-1720
Data Type:	article
DOI 連結:	http://dx.doi.org/10.1080/03610926.2012.719121
DOI:	10.1080/03610926.2012.719121
Appears in Collections:	[統計學系] 期刊論文

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