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政大機構典藏 > 理學院 > 神經科學研究所 > 期刊論文 > Item 140.119/99016

Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/99016

Title:	Neuroprotective mechanism of glial cell line-derived neurotrophic factor on dopamine neurons: effects on antioxidation.
Authors:	趙知章 CC, Chao;EHY, Lee
Contributors:	神科所
Keywords:	Glial cell line-derived neurotrophic factor;Glutathione peroxidase;Superoxide dismutase;Catalase;Dopamine;1-Methyl-4-phenylpyridinium
Date:	1999
Issue Date:	2016-07-13 14:31:13 (UTC+8)
Abstract:	Recombinant human GDNF was infused into the rat striatum either acutely or subchronically. Its effects and its interactions with MPP+ on antioxidant enzyme activities were examined. Results indicated that acute GDNF infusion significantly increased glutathione peroxidase, superoxide dismutase and catalase activities. Subchronic GDNF treatment decreased the DA level and enhanced DA turnover. Pre-treatment with GDNF markedly protected DA neurons against MPP+-induced toxicity. These results suggest that GDNF protects DA neurons through its activation of the antioxidant enzyme systems.
Relation:	Neuropharmacol., 38(6), 913-916
Data Type:	article
DOI 連結:	http://dx.doi.org/10.1016/S0028-3908(99)00030-1
DOI:	10.1016/S0028-3908(99)00030-1
Appears in Collections:	[神經科學研究所] 期刊論文

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