政大機構典藏-National Chengchi University Institutional Repository(NCCUR):Item 140.119/99016

English | 正體中文 | 简体中文 | Post-Print筆數 : 27 | Items with full text/Total items : 113648/144635 (79%)
Visitors : 51599637 Online Users : 772

RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.

Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer

政大機構典藏 > 理學院 > 神經科學研究所 > 期刊論文 > Item 140.119/99016

Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/99016

Title:	Neuroprotective mechanism of glial cell line-derived neurotrophic factor on dopamine neurons: effects on antioxidation.
Authors:	趙知章 CC, Chao;EHY, Lee
Contributors:	神科所
Keywords:	Glial cell line-derived neurotrophic factor;Glutathione peroxidase;Superoxide dismutase;Catalase;Dopamine;1-Methyl-4-phenylpyridinium
Date:	1999
Issue Date:	2016-07-13 14:31:13 (UTC+8)
Abstract:	Recombinant human GDNF was infused into the rat striatum either acutely or subchronically. Its effects and its interactions with MPP+ on antioxidant enzyme activities were examined. Results indicated that acute GDNF infusion significantly increased glutathione peroxidase, superoxide dismutase and catalase activities. Subchronic GDNF treatment decreased the DA level and enhanced DA turnover. Pre-treatment with GDNF markedly protected DA neurons against MPP+-induced toxicity. These results suggest that GDNF protects DA neurons through its activation of the antioxidant enzyme systems.
Relation:	Neuropharmacol., 38(6), 913-916
Data Type:	article
DOI 連結:	http://dx.doi.org/10.1016/S0028-3908(99)00030-1
DOI:	10.1016/S0028-3908(99)00030-1
Appears in Collections:	[神經科學研究所] 期刊論文

Files in This Item:

File	Description	Size	Format
913-916.pdf		54Kb	Adobe PDF2	617	View/Open

社群 sharing

著作權政策宣告 Copyright Announcement

1.本網站之數位內容為國立政治大學所收錄之機構典藏，無償提供學術研究與公眾教育等公益性使用，惟仍請適度，合理使用本網站之內容，以尊重著作權人之權益。商業上之利用，則請先取得著作權人之授權。
The digital content of this website is part of National Chengchi University Institutional Repository. It provides free access to academic research and public education for non-commercial use. Please utilize it in a proper and reasonable manner and respect the rights of copyright owners. For commercial use, please obtain authorization from the copyright owner in advance.

2.本網站之製作，已盡力防止侵害著作權人之權益，如仍發現本網站之數位內容有侵害著作權人權益情事者，請權利人通知本網站維護人員(nccur@nccu.edu.tw)，維護人員將立即採取移除該數位著作等補救措施。
NCCU Institutional Repository is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff(nccur@nccu.edu.tw). We will remove the work from the repository and investigate your claim.

Loading...