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    题名: Neuroprotective mechanism of glial cell line-derived neurotrophic factor on dopamine neurons: effects on antioxidation.
    作者: 趙知章
    CC, Chao;EHY, Lee
    贡献者: 神科所
    关键词: Glial cell line-derived neurotrophic factor;Glutathione peroxidase;Superoxide dismutase;Catalase;Dopamine;1-Methyl-4-phenylpyridinium
    日期: 1999
    上传时间: 2016-07-13 14:31:13 (UTC+8)
    摘要: Recombinant human GDNF was infused into the rat striatum either acutely or subchronically. Its effects and its interactions with MPP+ on antioxidant enzyme activities were examined. Results indicated that acute GDNF infusion significantly increased glutathione peroxidase, superoxide dismutase and catalase activities. Subchronic GDNF treatment decreased the DA level and enhanced DA turnover. Pre-treatment with GDNF markedly protected DA neurons against MPP+-induced toxicity. These results suggest that GDNF protects DA neurons through its activation of the antioxidant enzyme systems.
    關聯: Neuropharmacol., 38(6), 913-916
    数据类型: article
    DOI 連結: http://dx.doi.org/10.1016/S0028-3908(99)00030-1
    DOI: 10.1016/S0028-3908(99)00030-1
    显示于类别:[神經科學研究所] 期刊論文

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