政大機構典藏-National Chengchi University Institutional Repository(NCCUR):Item 140.119/90182
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    題名: 神經激胺在記憶上所扮演的角色
    作者: 陳美如
    貢獻者: 李小媛
    陳美如
    日期: 1989
    1988
    上傳時間: 2016-05-03 14:17:22 (UTC+8)
    摘要: 摘要
    過去研究發現median raphe 與dorsal raphe在解剖分化與功能反應上諸多不同，而5-hydroxytryptamine在記憶上扮演抑制或促進的角色，研究結果則不一致。本研究主要目的是以passive avoidance task為模式，探討5-hydroxytryptamine在記憶鞏固上所扮演的角色及mesolimbic serotonergic pathway 與mesostriatal serotonergic pathway在記憶上是否有分化現象。
    本研究採實驗法。實驗動物為雄性Sprague-Dawley種的大白鼠102隻。實驗分三部份進行，第一部份：側腦室；第二部份：海馬迴；第三部份：紋狀體，動物被隨機分派至控制組(注射ascorbic acid) 和實驗組(注射5，7-dihydroxytryptamine) 然後，測量控制組和實驗組在記憶上的表現及腦中5-hydroxytryptamine 與norepinephrine的差異。
    實驗結果採單因子變異數分析及曼─惠特尼U考驗。結果顯示：(l)記憶測量方面：在前腦和海馬迴實驗組與控制組沒達到顯著差異，而在紋狀體實驗組的表現明顯的高於控制組(2)化學分析方面：在前腦、海馬迴和紋狀體，實驗組的5-hydroxytryptamine明顯的低於控制組而兩組在norepinephrine上的差異均未達到顯著水準。其原因可能是5-hydroxytryptamine破壞程度不同，或則是5-hydroxytryptamine在腦中不同區域扮演不同的角色所致。
    參考文獻: 參考文獻
    一、中文部份
    1.林清山 心理與教育統計學 台北 東華書局 民62年。
    二、英文部分
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    18. LeeE. H.Y. (1986) Additive effects of apomorphine and colonidine on serotonin neurons in the dorsal raphe. Life Sciences, 40, 635-542.
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    21. Liang, K.C. and Lee, E.H.Y. (1988) Intra-amygdala injection of corticotropin releasing factor facilitate inhibitory avoidance learning and reduce exploratory behavior in rats. Psychopharmacology, 96, 232-236.
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    Studies on the role of central 5-HT neurons in avoidance learning: a behavioral and biochemical in serotonin: Current aspects of neurochemistry and function. edited by B. H aber. S. Gabay. M. R. Issidorides and S. G. A. Alivisatos New York Plenum Press, 681-705.
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    描述: 碩士
    國立政治大學
    心理學系
    資料來源: http://thesis.lib.nccu.edu.tw/record/#B2002005534
    資料類型: thesis
    顯示於類別:[心理學系] 學位論文

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