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    题名: 神經激胺在記憶上所扮演的角色
    作者: 陳美如
    贡献者: 李小媛
    陳美如
    日期: 1989
    1988
    上传时间: 2016-05-03 14:17:22 (UTC+8)
    摘要: 摘要
    過去研究發現median raphe 與dorsal raphe在解剖分化與功能反應上諸多不同，而5-hydroxytryptamine在記憶上扮演抑制或促進的角色，研究結果則不一致。本研究主要目的是以passive avoidance task為模式，探討5-hydroxytryptamine在記憶鞏固上所扮演的角色及mesolimbic serotonergic pathway 與mesostriatal serotonergic pathway在記憶上是否有分化現象。
    本研究採實驗法。實驗動物為雄性Sprague-Dawley種的大白鼠102隻。實驗分三部份進行，第一部份：側腦室；第二部份：海馬迴；第三部份：紋狀體，動物被隨機分派至控制組(注射ascorbic acid) 和實驗組(注射5，7-dihydroxytryptamine) 然後，測量控制組和實驗組在記憶上的表現及腦中5-hydroxytryptamine 與norepinephrine的差異。
    實驗結果採單因子變異數分析及曼─惠特尼U考驗。結果顯示：(l)記憶測量方面：在前腦和海馬迴實驗組與控制組沒達到顯著差異，而在紋狀體實驗組的表現明顯的高於控制組(2)化學分析方面：在前腦、海馬迴和紋狀體，實驗組的5-hydroxytryptamine明顯的低於控制組而兩組在norepinephrine上的差異均未達到顯著水準。其原因可能是5-hydroxytryptamine破壞程度不同，或則是5-hydroxytryptamine在腦中不同區域扮演不同的角色所致。
    參考文獻: 參考文獻
    一、中文部份
    1.林清山 心理與教育統計學 台北 東華書局 民62年。
    二、英文部分
    1. Archer Trevor (1982) Serotonin and fear retention in the rats. Journal of Comparative Psychology, 96(3), 491-516.
    2. Dahlstrom. A. and K. Fuxe. (1974) Evidence for the existence of monoamine-containing neurons in the central nervous system. Acta Physiol. Scand, 62: Supple. 232, 1-55,
    3. Essman, W.B. (19~3) Neuromolecular modulation of experimentally induedretrograde ammesia. Confinia neurology, 35, 1-22.
    4. Fibiger, H. C., Lepiane, F. G. and Phillips, A.G. (1987) Disruption of memory produced by stimulation of the dorsal raphe nucleus: mediation by serotonin. Brain Research. ISS. 380-386.
    5. Fuxe, K. (1965) "Evidence for the existence of monoamine neurons in the control nervous svstem." IV. Distribution of monoamine nerve terminals nervous in central svstem." Acta Physiol. Scand.64, Supple, 247, 37-85.
    6. Gekson, S. and Baldessarini, R.F. (1975) Selective destruction of serotonin terminals In rat forebrain by high dose of 5, 7-dihydroxytryptamine. Brain Research, 85, 140-145.
    7. Geyer, M.A. and Lee, E.H.Y. (1984) Effects of clonidine, piperoxane and locus coeruleus lesion on the serotonergic and dopaminergic system in raphe and caudate nucleus. Biochemical Pharmacology, 3399-3404.
    8. Geyer, M.A., Flicker, C.E. and Lee, E.H . Y. (1982) Effect of tactile startle on serotonin content of midbrain raphe neurons in rats. Behavioral Brain Research, 4, 369-376.
    9. Geyer, M.A., Puerto, Dawsey, W.J., Wilson, S.K, Ballard, p. and Mandel I .AJ. (1976) Histologic and enzymatic studies of the mesolimbic and mesosrriaral serotonergic pathways, Brain Research, 106, 241-256.
    10. Geyer, M.A., Puerto, Menkes, D.B.,Segal ,D.S and Mandell, A.J. (1976) Behavioral studies following lesions of the mesolimbic and mesostriatal serotonergic pathways. Brain Research, 106, 25 7-270.
    11. Geyer, M.A, Dawsey, W.J. and Mandell, A. J . (1975) Differential effect of caffeine, d-amphetamine and methylphenidate on individual raphe cell fluorescence: a microspectrofluorimetric demonstration. Brain Research, 85, 135-139.
    12. Jacobs, B., William and Taylar, K.M. (1974) Defferential behavioral and neurochemical effects fllowing lesion s of the dorsal or median. Brain Research, 79. 353-361.
    13. Lalonde, R. and V. Vikis-Freibergs (1982) Manipulation s of 5-HT activity and memory in the rat. Pharmacology Biochemistry & Behavior, 22, 377-382.
    14. Lee, E.H.Y. (1989) Role of septal 5-HT In memory formation in rat. In preparation.
    15. Lee. E.H.Y. (1989) Intra-hippocampal CRF injection Improve memory retention in rat. In preparation.
    16. Lee, E.H. Y., Lin.H.H and Yin.H.M. (1987) Differential influences of different stressors upon midbrain raphe neurons in rats. Neuroscience, 80, 115-119.
    17. Lee, E.H.Y., Wang. F.B., Tang,Y.P. and Geyer, M .A. (1987) Gabaergic interneurons in the dorsal raphe mediate the effects of apomorphine on sertonergic system. Brain Research Bulletin, 18. 345-353
    18. LeeE. H.Y. (1986) Additive effects of apomorphine and colonidine on serotonin neurons in the dorsal raphe. Life Sciences, 40, 635-542.
    19. Lee, E.M.Y and Geyer, M.A. (1984) Indirect effects of apomorphine on serotonergic neurons in rats. Neuroscience, 11(2), 437-442.
    20. Lee, E.H.Y and Geyer, M.A. (1982) Selective effects of apomorphine on dorsal raphe neurons: a cytofluorimetric studv. Brain Rese arch Bulletin, 9, 719-725.
    21. Liang, K.C. and Lee, E.H.Y. (1988) Intra-amygdala injection of corticotropin releasing factor facilitate inhibitory avoidance learning and reduce exploratory behavior in rats. Psychopharmacology, 96, 232-236.
    22. O"gren, S.O., Fuse, K., Archer. T. Hall, H., Holm, A.C. and Kohlor, C. (1981)
    Studies on the role of central 5-HT neurons in avoidance learning: a behavioral and biochemical in serotonin: Current aspects of neurochemistry and function. edited by B. H aber. S. Gabay. M. R. Issidorides and S. G. A. Alivisatos New York Plenum Press, 681-705.
    23. O"gren, S.O. (1982) Forebrain serotonin and avoidance learning: behavioral and biochemistry. Studies on one-wav active avoidance learning in male rat. Pharmacology Biochemistry & Behavioral, 16, 881-895.
    24. Peat. M.A .and Gibb, J, W. (1983) High-Performance liquid chromatographic determination of indoleamines, dopamine, and norepinephrine in rat brain with fluorometric detection. Analytical Biochemistry, 128. 275-280.
    25. Ponzio, F. and Jonsson, G. (1978) Effects of neonatal 5, 7-dihydroxytryptamine treatment on the development of serotonin neurons and their transmitter metabolism. Developmental neuroscience, 1, 80-89.
    26. Wetzell, W, Getsova, V.M., Jork, R. and Matthies, H (1979) Effect of serotonin on Y-maze retention and hippocampal protein synthesis in rats. Pharmacology Biochemistry & Behavior, 12, 319-322.
    描述: 碩士
    國立政治大學
    心理學系
    資料來源: http://thesis.lib.nccu.edu.tw/record/#B2002005534
    数据类型: thesis
    显示于类别:[心理學系] 學位論文

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