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    Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/135217


    Title: Contribution of Matrix Metalloproteinase-2 Promoter Genotypes to Nasopharyngeal Cancer Susceptibility and Metastasis in Taiwan
    Authors: 趙知章
    Chao, Chih-Chang
    Hsu, Shih-Wei
    Gong, Chi-Li
    Hsu, Huai-Mei
    Wang, Yun-Chi
    Chang, Wen-Shin
    Yueh-Ting Tsai, Liang-Chun Shih, Chia-Wen Tsai, DA-Tian Bau
    Contributors: 神科所
    Keywords: Genotype;MMP2;Taiwan;metastasis;nasopharyngeal cancer;polymorphism;susceptibility
    Date: 2019-07
    Issue Date: 2021-05-27 11:39:04 (UTC+8)
    Abstract: Background/Aim: Matrix metalloproteinase 2 (MMP2) is up-regulated in many cancers. However, the association of MMP2 genotype to nasopharyngeal cancer (NPC) susceptibility in Taiwan remains elusive. Materials and Methods: In this study, the role of MMP2 promoter C-1306T (rs243865) and C-735T (rs2285053) genotypes were investigated among 208 NPC patients and 416 healthy controls, and their role in NPC staging and TNM classifications were examined. Results: There was no differential distribution as for the genotypic or allelic frequencies at MMP2 promoter C-1306T or C-735T between the control and case groups. Noticeably, those with MMP2 C-1306T CT+TT genotypes had a lower metastatic risk than those with CC (p=0.0295). As for staging, T and N classifications, there was no differential distribution in C-1306T genotypes (p>0.05). Also, there was no differential distribution of C-735T genotypes according to different behavioral/clinicopathological characteristics. Conclusion: CT and TT genotypes at MMP2 C-1306T were associated with a significantly decreased risk of NPC metastasis.
    Relation: Cancer Genomics & Protemics, Vol.16, pp.287-292
    Data Type: article
    DOI 連結: https://doi.org/10.21873/cgp.20133
    DOI: 10.21873/cgp.20133
    Appears in Collections:[神經科學研究所] 期刊論文

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