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题名:	Contribution of Matrix Metalloproteinase-2 Promoter Genotypes to Nasopharyngeal Cancer Susceptibility and Metastasis in Taiwan
作者:	趙知章 Chao, Chih-Chang Hsu, Shih-Wei Gong, Chi-Li Hsu, Huai-Mei Wang, Yun-Chi Chang, Wen-Shin Yueh-Ting Tsai, Liang-Chun Shih, Chia-Wen Tsai, DA-Tian Bau
贡献者:	神科所
关键词:	Genotype;MMP2;Taiwan;metastasis;nasopharyngeal cancer;polymorphism;susceptibility
日期:	2019-07
上传时间:	2021-05-27 11:39:04 (UTC+8)
摘要:	Background/Aim: Matrix metalloproteinase 2 (MMP2) is up-regulated in many cancers. However, the association of MMP2 genotype to nasopharyngeal cancer (NPC) susceptibility in Taiwan remains elusive. Materials and Methods: In this study, the role of MMP2 promoter C-1306T (rs243865) and C-735T (rs2285053) genotypes were investigated among 208 NPC patients and 416 healthy controls, and their role in NPC staging and TNM classifications were examined. Results: There was no differential distribution as for the genotypic or allelic frequencies at MMP2 promoter C-1306T or C-735T between the control and case groups. Noticeably, those with MMP2 C-1306T CT+TT genotypes had a lower metastatic risk than those with CC (p=0.0295). As for staging, T and N classifications, there was no differential distribution in C-1306T genotypes (p>0.05). Also, there was no differential distribution of C-735T genotypes according to different behavioral/clinicopathological characteristics. Conclusion: CT and TT genotypes at MMP2 C-1306T were associated with a significantly decreased risk of NPC metastasis.
關聯:	Cancer Genomics & Protemics, Vol.16, pp.287-292
数据类型:	article
DOI 連結:	https://doi.org/10.21873/cgp.20133
DOI:	10.21873/cgp.20133
显示于类别:	[神經科學研究所] 期刊論文

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