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政大典藏 > College of Science > Graduate Institute of Applied Physics > Periodical Articles > Item 140.119/79425

Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/79425

Title:	Investigation of Readout RF Pulse Impact on the Chemical Exchange Saturation Transfer Spectrum
Authors:	Huang, Sheng-Min;Jan, Meei-Ling;Liang, Hsin-Chin;Chang, Chia-Hao;Wu, Yi-Chun;Tsai, Shang-Yueh;Wang, Fu-Nien 蔡尚岳
Contributors:	應物所
Date:	2015-10
Issue Date:	2015-11-25 16:37:06 (UTC+8)
Abstract:	Chemical exchange saturation transfer magnetic resonance imaging (CEST-MRI) is capable of both microenvironment and molecular imaging. The optimization of scanning parameters is important since the CEST effect is sensitive to factors such as saturation power and field homogeneity. The aim of this study was to determine if the CEST effect would be altered by changing the length of readout RF pulses. Both theoretical computer simulation and phantom experiments were performed to examine the influence of readout RF pulses. Our results showed that the length of readout RF pulses has unremarkable impact on the Z-spectrum and CEST effect in both computer simulation and phantom experiment. Moreover, we demonstrated that multiple refocusing RF pulses used in rapid acquisition with relaxation enhancement (RARE) sequence induced no obvious saturation transfer contrast. Therefore, readout RF pulse has negligible effect on CEST Z-spectrum and the optimization of readout RF pulse length can be disregarded in CEST imaging protocol.
Relation:	Scientific Reports, 5, 15062
Data Type:	article
DOI link:	http://dx.doi.org/10.1038/srep15062
DOI:	10.1038/srep15062
Appears in Collections:	[Graduate Institute of Applied Physics] Periodical Articles

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