政大機構典藏-National Chengchi University Institutional Repository(NCCUR):Item 140.119/76070
English  |  正體中文  |  简体中文  |  Post-Print筆數 : 27 |  Items with full text/Total items : 113656/144643 (79%)
Visitors : 51740779      Online Users : 586
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version


    Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/76070


    Title: The clinical implications of hepatitis B virus genotype: Recent advances
    Authors: Lin, Chih-Lin
    林志陵
    Kao, J.-H.
    Contributors: 心理系
    Keywords: alpha interferon;hepatitis B(e) antigen;lamivudine;nucleoside;nucleoside derivative;peginterferon alpha;telbivudine;virus DNA;antiviral therapy;chronic hepatitis;chronicity;controlled study;disease course;gene interaction;gene mutation;genetic difference;genotype;geographic distribution;hepatitis B;Hepatitis B virus;human;liver cell carcinoma;liver cirrhosis;liver disease;low drug dose;mutation rate;nonhuman;outcome assessment;priority journal;promoter region;review;risk assessment;seroconversion;treatment response;virus identification;virus load;virus mutant;virus pathogenesis;virus transmission;virus typing
    Date: 2011-01
    Issue Date: 2015-06-23 15:49:18 (UTC+8)
    Abstract: Outcomes of chronic hepatitis B virus (HBV) infection are heterogeneous. Estimates of annual incidence of cirrhosis and hepatocellular carcinoma (HCC) are 2-10% and 1-3%, respectively. Several viral factors, including HBV genotype, viral load and specific viral mutations, have been associated with disease progression. Among these, HBV genotype is not only predictive of clinical outcomes but has also been associated with response to interferon treatment. Currently, at least 10 HBV genotypes and several subtypes have been identified; they have distinct geographic distribution. Acute infection with genotypes A and D results in higher rates of chronicity than genotypes B and C. Compared to genotype A and B cases, patients with genotypes C and D have lower rates of spontaneous hepatitis B e antigen (HBeAg) seroconversion; when this occurs, it tends to be delayed. HBV genotype C has a higher frequency of basal core promoter (BCP) A1762T/G1764A mutation, pre-S deletion and is associated with higher viral load than genotype B. Similarly, genotype D has a higher prevalence of BCP A1762T/G1764A mutation than genotype A. These observations suggest important pathogenic differences between HBV genotypes. These may contribute to more severe liver disease, including cirrhosis and HCC with genotypes C and D HBV infection. In addition, genotype A and B patients have better responses to interferon-based therapy than genotypes C and D, but there are few consistent differences for direct HBV antivirals. In conclusion, genotyping of chronic HBV infections can help practicing physicians identify those at risk of disease progression and determine optimal anti-viral therapy. © 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
    Relation: Journal of Gastroenterology and Hepatology (Australia), 26(SUPPL. 1), 123-130
    Data Type: article
    DOI link: http://dx.doi.org/10.1111/j.1440-1746.2010.06541.x
    DOI: 10.1111/j.1440-1746.2010.06541.x
    Appears in Collections:[Department of Psychology] Periodical Articles

    Files in This Item:

    File Description SizeFormat
    j.1440-1746.2010.06541.x.pdf469KbAdobe PDF2725View/Open


    All items in 政大典藏 are protected by copyright, with all rights reserved.


    社群 sharing

    著作權政策宣告 Copyright Announcement
    1.本網站之數位內容為國立政治大學所收錄之機構典藏，無償提供學術研究與公眾教育等公益性使用，惟仍請適度，合理使用本網站之內容，以尊重著作權人之權益。商業上之利用，則請先取得著作權人之授權。
    The digital content of this website is part of National Chengchi University Institutional Repository. It provides free access to academic research and public education for non-commercial use. Please utilize it in a proper and reasonable manner and respect the rights of copyright owners. For commercial use, please obtain authorization from the copyright owner in advance.

    2.本網站之製作，已盡力防止侵害著作權人之權益，如仍發現本網站之數位內容有侵害著作權人權益情事者，請權利人通知本網站維護人員(nccur@nccu.edu.tw)，維護人員將立即採取移除該數位著作等補救措施。
    NCCU Institutional Repository is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff(nccur@nccu.edu.tw). We will remove the work from the repository and investigate your claim.
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback