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    Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/75234


    Title: Hepatitis B virus genotypes: Clinical relevance and therapeutic implications
    Authors: Lin, Chih-Lin
    林志陵
    Kao, J.-H.
    Contributors: 心理系
    Keywords: adefovir dipivoxil;antivirus agent;entecavir;interferon;lamivudine;nucleoside derivative;nucleotide derivative;peginterferon;telbivudine;tenofovir disoproxil;article;cancer risk;drug efficacy;drug response;genetic association;genetic variability;genotype;geographic distribution;hepatitis B;Hepatitis B virus;high risk patient;human;immune response;liver cell carcinoma;low drug dose;molecular epidemiology;nonhuman;outcome assessment;prognosis;recurrent disease;risk assessment;seroconversion;virus genome;virus load;virus replication;virus virulence
    Date: 2013-06
    Issue Date: 2015-05-21 16:24:25 (UTC+8)
    Abstract: At least ten hepatitis B virus (HBV) genotypes (A to J) with distinct geographic distributions have been recognized. HBV genotype is not only predictive of clinical outcome but also implicated in responsiveness to antiviral therapy, especially interferon-based regimens. HBV genotype-specific immunologic and virological pathogenesis may contribute to heterogeneous clinical outcomes in chronic hepatitis B patients. For example, patients with genotypes C and D infection have a lower rate of spontaneous HBeAg seroconversion. In addition, genotype C and D have a higher frequency of basal core promoter A1762T/G1764A mutation than genotype A and B. Genotypes C and D also carry a higher risk of cirrhosis and HCC development than genotype A and B. Therapeutically, genotype A and B patients have a better response to interferon-based therapy than genotypes C and D patients, but the response to nucleos(t)ide analogues is comparable across all HBV genotypes. In conclusion, genotyping of HBV can help practicing physicians identify chronic hepatitis B patients who are at risk of disease progression and optimize anti-viral therapy in clinical practice. © 2013 Springer Science+Business Media New York.
    Relation: Current Hepatitis Reports, 12(2), 124-132
    Data Type: article
    DOI link: http://dx.doi.org/10.1007/s11901-013-0166-6
    DOI: 10.1007/s11901-013-0166-6
    Appears in Collections:[Department of Psychology] Periodical Articles

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