政大機構典藏-National Chengchi University Institutional Repository(NCCUR):Item 140.119/75233
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    题名: Hepatitis B viral factors and treatment responses in chronic hepatitis B
    作者: Lin, Chih-Lin
    林志陵
    Kao, J.-H.
    贡献者: 心理系
    关键词: adefovir;adefovir dipivoxil;alanine aminotransferase;alpha interferon;creatinine;entecavir;hepatitis B surface antigen;lamivudine;peginterferon alpha;peginterferon alpha2a;peginterferon alpha2b;telbivudine;tenofovir disoproxil;virus DNA;antiviral resistance;antiviral therapy;clinical effectiveness;competitive inhibition;creatinine blood level;disease association;disease exacerbation;drug efficacy;drug half life;genotype;hepatitis B;Hepatitis B virus;human;liver cirrhosis;monotherapy;mutational analysis;nephrotoxicity;predictive value;review;risk factor;seroconversion;side effect;treatment duration;treatment response;viremia;virus strain;Antiviral Agents;DNA, Viral;Hepatitis B e Antigens;Hepatitis B Surface Antigens;Hepatitis B virus;Hepatitis B, Chronic;Humans;Interferon-alpha;Lamivudine;Polyethylene Glycols;Recombinant Proteins
    日期: 2013-06
    上传时间: 2015-05-21 16:24:11 (UTC+8)
    摘要: Baseline and on-treatment hepatitis B viral factors are reported to affect treatment responses. A lower baseline hepatitis B virus (HBV) DNA level is a strong predictor of the response to antiviral therapy. HBV genotype A/B patients have better responses to interferon-based therapy than those with genotypes C/D. Regarding the association of HBV mutants with responses to antiviral therapy, current evidence is limited. On-treatment viral suppression is the most important predictor of response to nucleoside analogs. On-treatment hepatitis B surface antigen decline is significantly associated with response to pegylated interferon. In the future, individualized therapy should be based on treatment efficacy, adverse effects, baseline and on-treatment predictors of antiviral therapy. © 2012, Elsevier Taiwan LLC & Formosan Medical Association.
    關聯: Journal of the Formosan Medical Association, 112(6), 302-311
    数据类型: article
    DOI 連結: http://dx.doi.org/10.1016/j.jfma.2013.02.001
    DOI: 10.1016/j.jfma.2013.02.001
    显示于类别:[心理學系] 期刊論文

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