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    题名: Single-Shot Magnetic Resonance Spectroscopic Imaging with Partial Parallel Imaging
    作者: Posse, Stefan;Otazo, Ricardo;Tsai, Shang-Yueh;Yoshitomo, Akio Ernesto;Lin, Fa-Hsuan
    蔡尚岳
    贡献者: 應物所
    关键词: magnetic resonance spectroscopic imaging;single-shot encoding;proton–echo-planar-spectroscopic-imaging;parallel imaging;SENSE;spectral quantification
    日期: 2009.03
    上传时间: 2014-04-10 11:16:07 (UTC+8)
    摘要: A magnetic resonance spectroscopic imaging (MRSI) pulse sequence based on proton-echo-planar-spectroscopic-imaging (PEPSI) is introduced that measures two-dimensional metabolite maps in a single excitation. Echo-planar spatial-spectral encoding was combined with interleaved phase encoding and parallel imaging using SENSE to reconstruct absorption mode spectra. The symmetrical k-space trajectory compensates phase errors due to convolution of spatial and spectral encoding. Single-shot MRSI at short TE was evaluated in phantoms and in vivo on a 3-T whole-body scanner equipped with a 12-channel array coil. Four-step interleaved phase encoding and fourfold SENSE acceleration were used to encode a 16 x 16 spatial matrix with a 390-Hz spectral width. Comparison with conventional PEPSI and PEPSI with fourfold SENSE acceleration demonstrated comparable sensitivity per unit time when taking into account g-factor-related noise increases and differences in sampling efficiency. LCModel fitting enabled quantification of inositol, choline, creatine, and N-acetyl-aspartate (NAA) in vivo with concentration values in the ranges measured with conventional PEPSI and SENSE-accelerated PEPSI. Cramer-Rao lower bounds were comparable to those obtained with conventional SENSE-accelerated PEPSI at the same voxel size and measurement time. This single-shot MRSI method is therefore suitable for applications that require high temporal resolution to monitor temporal dynamics or to reduce sensitivity to tissue movement.
    關聯: Magnetic Resonance in Medicine ,61(3), 541-547
    数据类型: article
    DOI 連結: http://dx.doi.org/10.1002/mrm.21855
    DOI: 10.1002/mrm.21855
    显示于类别:[應用物理研究所 ] 期刊論文

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