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Title:	Inflow-weighted pulmonary perfusion: Comparison between dynamic contrast-enhanced MRI versus perfusion scintigraphy in complex pulmonary circulation
Authors:	蔡尚岳 Lin,Yi-Ru;Tsai,Shang-Yueh;Huang,Teng-Yi;Chung,Hsiao-Wen;Huang,Yi-Luan;Wu,Fu-Zong;Lin, Chu-Chuan;Peng, Nan-Jing;Wu,Ming-Ting
Contributors:	應物所
Keywords:	Pulmonary perfusion;MRI;Pulmonary scintigraphy;Dynamic contrast enhancement-MRI
Date:	2013-03
Issue Date:	2013-11-27 16:09:18 (UTC+8)
Abstract:	Background: Due to the different properties of the contrast agents, the lung perfusion maps as measured by 99mTc-labeled macroaggregated albumin perfusion scintigraphy (PS) are not uncommonly discrepant from those measured by dynamic contrast-enhanced MRI (DCE-MRI) using indicator-dilution analysis in complex pulmonary circulation. Since PS offers the pre-capillary perfusion of the first-pass transit, we hypothesized that an inflow-weighted perfusion model of DCE-MRI could simulate the result by PS. Methods: 22 patients underwent DCE-MRI at 1.5T and also PS. Relative perfusion contributed by the left lung was calculated by PS (PSL%), by DCE-MRI using conventional indicator dilution theory for pulmonary blood volume (PBVL%) and pulmonary blood flow (PBFL%) and using our proposed inflow-weighted pulmonary blood volume (PBViwL%). For PBViwL%, the optimal upper bound of the inflow-weighted integration range was determined by correlation coefficient analysis. Results: The time-to-peak of the normal lung parenchyma was the optimal upper bound in the inflow-weighted perfusion model. Using PSL% as a reference, PBVL% showed error of 49.24% to −40.37% (intraclass correlation coefficient RI = 0.55) and PBFL% had error of 34.87% to −27.76% (RI = 0.80). With the inflow-weighted model, PBViwL% had much less error of 12.28% to −11.20% (RI = 0.98) from PSL%. Conclusions: The inflow-weighted DCE-MRI provides relative perfusion maps similar to that by PS. The discrepancy between conventional indicator-dilution and inflow-weighted analysis represents a mixed-flow component in which pathological flow such as shunting or collaterals might have participated.
Relation:	Journal of cardiovascular magnetic resonance ,15(21)
Data Type:	article
DOI link:	http://dx.doi.org/10.1186/1532-429X-15-21
DOI:	10.1186/1532-429X-15-21
Appears in Collections:	[Graduate Institute of Applied Physics] Periodical Articles

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