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政大機構典藏 > 理學院 > 神經科學研究所 > 國科會研究計畫 > Item 140.119/55526

Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/55526

Title:	骨形成蛋白於神經肌肉系統功能之研究
Other Titles:	Role of Bone Morphogenetic Proteins in the Neuromuscular System
Authors:	王培育
Contributors:	國立政治大學神經科學研究所行政院國家科學委員會
Keywords:	基礎醫學;骨形成蛋白;神經肌肉系統
Date:	2010
Issue Date:	2012-11-15 11:24:03 (UTC+8)
Abstract:	The naturally occurring cell death of developing motor neurons is considered to be guided by the influence of their peripheries (Hamburger, 1934, 1958). Skeletal muscle cells have been implicated as a key source of peripheral-derived survival factors, as the absence of them causes a near total loss of developing motor neurons (Grieshammer et al., 1998). Many neuronal cell types are controlled by a small number of survival factors, with the genetic deletion of a single factor leading to a profound loss of neurons (Lindsay, 1996). Motor neurons, in contrast, appear to be controlled by numerous survival factors. The null mutation of a single, or even multiple, factors only leads to partial loss of motor neurons (Liu and Jaenisch, 2000; Oppenheim et al., 2000; Oppenheim et al., 2001). This may indicate that there are distinct subpopulations of motor neurons (Oppenheim et al., 2000). Equally, it implies that muscle fibers produce more than one regulator of motor neurons, as the consequence of the genetic deletion of them type is more profound than the deletion of any growth factor.
Relation:	基礎研究學術補助研究期間:9908~ 10007 研究經費:1400仟元
Data Type:	report
Appears in Collections:	[神經科學研究所] 國科會研究計畫

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