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    题名: Differential effects of dopamine D1 and D2 receptor antagonists on conditioned orienting behavior in the rat
    作者: Chang, Yea-Huey
    Liao, Ruey-Ming
    廖瑞銘
    贡献者: 國立政治大學心理學系
    关键词: SCH23390;raclopride;appetitive Pavlovian conditioning;associative learning;acquisition;expression
    日期: 2003-03
    上传时间: 2008-12-31 10:47:20 (UTC+8)
    摘要: Brain dopamine (DA) systems are known to be important in regulation of behavior conditioned to
    appetitive stimuli. Nevertheless, despite a large body of evidence showing behavioral deficits in the
    operant conditioning paradigm produced by DA receptor blockade, there have been relatively few
    studies directly assessing behavioral changes in classical conditioning paradigm under this drug
    treatment. By employing an appetitive Pavlovian conditioning task, the present work investigated the
    effects of selective D1
    and D2
    receptor antagonists on the expression and acquisition of the conditioned
    orienting response (COR) and food-cup approach. SCH23390 (0, 0.05, and 0.10 mg/kg) and raclopride
    (0, 0.1, and 0.2 mg/kg) were administered via an intra-peritoneal route in a between-group design. Data
    from Experiment 1 showed that both SCH23390 and raclopride suppressed expression of the COR and
    food-cup approach, but only the impairment produced by raclopride reached a significant level. In
    Experiment 2, with SCH23390 being administered during the acquisition phase, the suppressed COR
    was completely restored in a subsequent (24 h later) drug-free session. In contrast, the suppressed COR
    in raclopride-pretreated groups was only partially restored. These findings support the view that the
    DA system plays a role in the neural substrates underlying this appetitive conditioning. In addition, D2
    receptors are more likely involved in the modulation of learning process of the COR than D1
    receptors.
    關聯: Chinese Journal of Physiology, 46(4), 159-168
    数据类型: article
    显示于类别:[心理學系] 期刊論文

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