政大機構典藏-National Chengchi University Institutional Repository(NCCUR):Item 140.119/20681
English  |  正體中文  |  简体中文  |  Post-Print筆數 : 27 |  全文筆數/總筆數 : 114401/145431 (79%)
造訪人次 : 53124716      線上人數 : 541
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    政大機構典藏 > 理學院 > 心理學系 > 期刊論文 >  Item 140.119/20681


    請使用永久網址來引用或連結此文件: https://nccur.lib.nccu.edu.tw/handle/140.119/20681


    題名: Chronic Effects of Haloperidol and SCH23390 on Operant and Licking Behaviors in the Rat
    作者: 廖瑞銘
    柯美全
    日期: 1995-06
    上傳時間: 2008-12-31 10:45:06 (UTC+8)
    摘要: Behavioral effects under chronic treatment of haloperidol and SCH23390 were examined for 18 days. Water deprived rats were trained either to perform an operant response on a fixed ratio 20 (FR20) schedule of reinforcement or to lick from a tube in a separate test. Both drugs completely impaired operant responding over all chronic administration days. Whether the lick performance was significantly affected differed depending upon the variable measured in that task. In contrast to the operant results, analysis of the microstructure of licking revealed very distinctive profiles of licking for each drug. Although the lick volume was consistantly reduced by both drugs across days, the decreased numbers of licks first observed were subsequently reversed back to the control level. However, the time courses and the reversal patterns were different for each drug. Haloperidol persistantly reduced the burst size for licking, whereas SCH23390 gradually enlarged it. For interlick interval (ILI) data, haloperidol had more impact on licks with longer ILI without influencing licks of shorter ILI. Contrarily, SCH23390 tended to lengthen the licks with shorter ILI without prolonging them enough to be classified as longer ILI licks. The dissociation of behavioral effects induced by chronic treatment of haloperidol and SCH23390 can be attributed to the drugs` blockade of different DA receptor subtypes. Also, the present study illustrates that using multiple behavioral tasks can be helpful to differentiate the subtle drug actions induced by DA receptor antagonists.
    關聯: Chinese Journal of Physiology, 38(2), 65-73
    資料類型: article
    顯示於類別:[心理學系] 期刊論文
    [神經科學研究所] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    p88.pdf28KbAdobe PDF21870檢視/開啟


    在政大典藏中所有的資料項目都受到原著作權保護.


    社群 sharing

    著作權政策宣告 Copyright Announcement
    1.本網站之數位內容為國立政治大學所收錄之機構典藏，無償提供學術研究與公眾教育等公益性使用，惟仍請適度，合理使用本網站之內容，以尊重著作權人之權益。商業上之利用，則請先取得著作權人之授權。
    The digital content of this website is part of National Chengchi University Institutional Repository. It provides free access to academic research and public education for non-commercial use. Please utilize it in a proper and reasonable manner and respect the rights of copyright owners. For commercial use, please obtain authorization from the copyright owner in advance.

    2.本網站之製作，已盡力防止侵害著作權人之權益，如仍發現本網站之數位內容有侵害著作權人權益情事者，請權利人通知本網站維護人員(nccur@nccu.edu.tw)，維護人員將立即採取移除該數位著作等補救措施。
    NCCU Institutional Repository is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff(nccur@nccu.edu.tw). We will remove the work from the repository and investigate your claim.
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋