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| 題名: | Lactobacillus fermentum PS150 promotes non-rapid eye movement sleep in the first night effect of mice |
| 作者: | 陳玠文
Chen, Chieh-Wen;Lin, Alexander;Shih, Ching-Ting;Chu, Hsu-Feng;Cheng, Yu-Ting;Wu, Chien-Chen;Yang, Cheryl C. H.;Tsai, Ying-Chieh |
| 貢獻者: | 神科所 |
| 日期: | 2021-08 |
| 上傳時間: | 2025-06-13 09:25:30 (UTC+8) |
| 摘要: | The first night effect (FNE) is a type of sleep disturbance caused by an unfamiliar environment, which leads to difficulty falling asleep and reduced sleep duration. Previously, we reported that Lactobacillus fermentum PS150 (PS150) improves sleep conditions in a pentobarbital-induced sleep mouse model. In this study, we aimed to evaluate the effect of PS150 on the FNE in mice. Briefly, mice were implanted with electrodes and orally administered PS150 for four weeks, and then the FNE was induced by cage changing. Analysis of polysomnographic signals revealed that intervention with PS150 restored non-rapid eye movement (NREM) sleep length under the FNE. Compared to diphenhydramine, a commonly used sleep aid, PS150 had no unwanted side effects, such as rapid eye movement (REM) sleep deprivation and fragmented sleep. Moreover, temporal analysis revealed that PS150 efficiently reduced both sleep latency and time spent restoring normal levels of REM sleep. Taken together, these results suggest that PS150 efficiently ameliorates sleep disturbance caused by the FNE. Additionally, V3–V4 16S rRNA sequencing revealed significant increases in Erysipelotrichia, Actinobacteria, and Coriobacteriia in fecal specimens of the PS150-treated group, indicating that PS150 induces gut microbiota remodeling. |
| 關聯: | Scientific Reports, Vol.11, Article number: 16313 |
| 資料類型: | article |
| DOI 連結: | https://doi.org/10.1038/s41598-021-95659-3 |
| DOI: | 10.1038/s41598-021-95659-3 |
| 顯示於類別: | [神經科學研究所] 期刊論文
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