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    题名: Baseline-dependent enhancement of working memory by memantine in male rats: Involvement of NMDA receptor subunits and CaMKII signaling
    作者: 趙知章
    Chao, Chih-Chang;Chen, Shuo-Fu;Cheng, Wan-Ju;Kuo, Chun-Hsien;Liao, Ruey-Ming
    贡献者: 神科所
    关键词: NMDA receptor antagonist;Cognitive enhancement;Dorsal striatum;Nucleus accumbens;Amygdala
    日期: 2024-12
    上传时间: 2025-02-24 15:56:12 (UTC+8)
    摘要: N-methyl-d-aspartate (NMDA) receptors, activated by glutamate, play a crucial role in learning and memory. Memantine (MEM), a non-competitive NMDA receptor antagonist, is currently prescribed for the treatment of Alzheimer's disease or dementia, which meanwhile simultaneously promotes a need to clarify its potential pro-cognitive effects that exist in normal healthy individuals. However, the neurobehavioral mechanisms underlying the cognitive improvement by MEM in normal individuals remain to be elucidated. This study aimed to assess the effects of MEM on working memory, measured by a discrete paired-trial delay alternation task in a T-maze in normal male rats. The impacts of MEM were hypothesized to vary depending on different baseline levels of working memory performance. Neurochemical examination of the levels of calcium/calmodulin-dependent kinase 2 (CaMKII) and NMDA receptor subunits within five targeted brain regions was conducted after behavioral tests. The results showed that acute administration of MEM enhanced working memory performance, with 2.5, 5.0, and 10 mg/kg doses increasing task accuracy compared to the vehicle, particularly in low performers. Neurochemically, the protein expression of CaMKII in the amygdala and that of the glutamate (Glu) N2A subunit in the dorsal striatum were greater in the low-performance group than in the high-performance group. Additionally, the protein expression of the GluN2A subunit in the dorsal striatum was negatively associated with task performance at baseline. The expression of GluN1 and GluN2B in the nucleus accumbens was negatively associated with task performance in the retest three weeks after drug treatment. These findings underscore the baseline-dependent improvement of working memory resulting from MEM administration, with observed drug effects associated with alterations in the levels of NMDA receptor subunits in striatal subareas and CaMKII in the amygdala.
    關聯: Pharmacology Biochemistry and Behavior, Vol.245, 173904
    数据类型: article
    DOI 連結: https://doi.org/10.1016/j.pbb.2024.173904
    DOI: 10.1016/j.pbb.2024.173904
    显示于类别:[神經科學研究所] 期刊論文

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