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    题名: N,Ndimethylglycine prevents toluene-induced impairment in recognition memory and synaptic plasticity in mice
    作者: 詹銘煥
    Chan, Ming-Huan
    Chung-PinHsieh
    HaoChen
    LinyiChen
    Hwei-HsienChen
    贡献者: 神科所
    日期: 2020-12
    上传时间: 2021-10-27 10:58:01 (UTC+8)
    摘要: Toluene intoxication produces deleterious effects on cognitive function, which has been associated with the inhibition of N-methyl-d-aspartate receptor (NMDAR). The present study determined whether N,N-dimethylglycine (DMG), a nutrient supplement and a partial agonist for NMDAR glycine binding site, could counteract recognition memory deficits and hippocampal synaptic dysfunction after acute toluene exposure. Male ICR mice were treated with toluene (250−750 mg/kg) for monitoring the sociability and social novelty in three-chamber test and long-term potentiation (LTP) of hippocampal synaptic transmission. Moreover, the combined effects of DMG (30−100 mg/kg) pretreatment with toluene (750 mg/kg) on three-chamber test, novel location and object recognition test and synaptic function were determined. Toluene decreased the sociability, preference for social novelty, hippocampal synaptic transmission and LTP in a dose-dependent manner. DMG pretreatment significantly reduced the toluene-induced memory impairment in social recognition, object location and object recognition and synaptic dysfunction. Furthermore, NMDAR glycine binding site antagonist, 7-chlorokynurenic acid, abolished the protective effects of DMG. These results indicate that DMG could prevent toluene-induced recognition memory deficits and synaptic dysfunction and its beneficial effects might be associated with modulation of NMDAR. These findings suggest that DMG supplementation might be an effective approach to prevent memory problems for the workers at risk of high-level toluene exposure or toluene abusers.
    關聯: Toxicology, No.446, pp.152613
    数据类型: article
    DOI 連結: https://doi.org/10.1016/j.tox.2020.152613
    DOI: 10.1016/j.tox.2020.152613
    显示于类别:[神經科學研究所] 期刊論文

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