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    題名: Neurobiological changes in striatal glutamate are associated with trait impulsivity of differential reinforcement of low-rate-response behavior in male rats
    作者: 廖瑞銘;顏乃欣;趙知章
    Liao, Ruey-Ming;Yen, Nai-Shing;Chao, Chih-Chang;Chuang, Chuen-Yu;Tsai, Shang-Yueh;Chen, Shuo-Fu;Yang, Yi-Hua
    貢獻者: 心理系;神科所
    關鍵詞: Magnetic resonance spectroscopy;Amino acid neurotransmitters;Striatal subregions;NMDA receptor subunits;Timing impulsivity
    日期: 2021-01
    上傳時間: 2021-05-27 10:43:23 (UTC+8)
    摘要: Impulsive action can be measured using rat`s responses on a differential reinforcement of low-rate-response (DRL) task in which performance may be varied between rats. Nevertheless, neurobiological profiles underlying the trait impulsivity of DRL behavior remain largely unknown. Here, in vivo non-invasive proton magnetic resonance spectroscopy (1H-MRS) and Western blot assay were performed to assess neurobiological changes in the dorsal striatum (DS) and nucleus accumbens (NAc) in relation to individual differences in DRL behavior. A cohort of rats was subjected to acquire a DRL task over 14 daily sessions. High impulsive (HI) and low impulsive (LI) rats were screened by behavioral measures displaying a lower response efficiency and performing more nonreinforced responses in HI rats and vice versa. MRS measurements indicated that the HI group had a lower NAc glutamate (Glu) level than did the LI group, whereas no such difference was found in the other five metabolites in this area. Moreover, no intergroup difference was observed in any metabolite in the DS. The results of Western blot assay revealed that protein expressions of GluN1 (but not GluN2B) subunit of N-methyl-D-aspartate receptors in the DS and NAc were higher in the HI group than in the LI group. This inherent timing impulsivity was not attributed to risky behavioral propensity because both Hl and LI rats could acquire a risk-dependent choice. The findings of this study, supported by certain correlations among behavioral, brain imaging, and neuroreceptor indices, provide evidence of the neurobiological changes of striatal Glu underlying trait impulsive action of DRL behavior.
    關聯: Neurobiology of Learning and Memory, Vol.177, 107352
    資料類型: article
    DOI 連結: https://doi.org/10.1016/j.nlm.2020.107352
    DOI: 10.1016/j.nlm.2020.107352
    顯示於類別:[心理學系] 期刊論文
    [神經科學研究所] 期刊論文

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