政大機構典藏-National Chengchi University Institutional Repository(NCCUR):Item 140.119/130350
English  |  正體中文  |  简体中文  |  Post-Print筆數 : 27 |  Items with full text/Total items : 113656/144643 (79%)
Visitors : 51733170      Online Users : 570
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version


    Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/130350


    Title: Identification of alternative splicing characteristic associated with clear-cell ovarian cancer from paired normal and tumor tissues
    Authors: 張家銘
    HUANG, YU-TING
    SHIAO, MENG-SHIN
    TSAI, CHEN-AN
    LAN, KUER-YUAN
    LIN, CHIEH-HSI
    JIANAWATH, NATINI
    Contributors: 資科系
    Date: 2019-07
    Issue Date: 2020-06-24 11:03:52 (UTC+8)
    Abstract: Alternative splicing of messenger RNAs (mRNAs) is a common and conserved biological process in eukaryotes. The aberrancy or disruption of different alternative splicing forms may cause alterations of cell functions and result in diseases. It is proposed that alternative splicing may play a critical role in the mechanisms of carcinogenesis. By studying a large dataset in The Cancer Genome Atlas database, a recent study showed that alternative splicing, particularly exon-exclusion, is a powerful prognosis factor in serious subtype of ovarian cancer. However, the characteristics of alternative splicing has not been studied in other subtypes. In this study, we focus on the alternative splicing events, i.e. single exon-inclusion or -exclusion, in clear-cell ovarian cancer subtype. The subtype appears to have particularly high incidence in Asians comparing to Europeans and Americans and tend to be drug resistant. Transcriptomes were obtained from tumors and their paired-normal tissues from five patients. PSI-values, which represent the proportions of alternative splicing events of an exon, were calculated in both tumor and paired-normal tissues. Differences of PSI-values between tumors and paired-normal were examined by a significant test based on Conditional Beta Regression model. In total, we identified ~200 exons covering 52 genes with significant differences between cancer and paired-normal tissue (p <; 0.001) including gene ERP29 and PAM which were previously identified in serous subtypes.
    Relation: IEEE Xplore and EI, IEEE the Systems, Man, and Cybernetics Society, pp.1-5
    Data Type: conference
    DOI link: https://doi.org/10.1109/ICMLC48188.2019.8949316
    DOI: 10.1109/ICMLC48188.2019.8949316
    Appears in Collections:[Department of Computer Science ] Proceedings

    Files in This Item:

    File Description SizeFormat
    496.pdf422KbAdobe PDF2209View/Open


    All items in 政大典藏 are protected by copyright, with all rights reserved.


    社群 sharing

    著作權政策宣告 Copyright Announcement
    1.本網站之數位內容為國立政治大學所收錄之機構典藏，無償提供學術研究與公眾教育等公益性使用，惟仍請適度，合理使用本網站之內容，以尊重著作權人之權益。商業上之利用，則請先取得著作權人之授權。
    The digital content of this website is part of National Chengchi University Institutional Repository. It provides free access to academic research and public education for non-commercial use. Please utilize it in a proper and reasonable manner and respect the rights of copyright owners. For commercial use, please obtain authorization from the copyright owner in advance.

    2.本網站之製作，已盡力防止侵害著作權人之權益，如仍發現本網站之數位內容有侵害著作權人權益情事者，請權利人通知本網站維護人員(nccur@nccu.edu.tw)，維護人員將立即採取移除該數位著作等補救措施。
    NCCU Institutional Repository is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff(nccur@nccu.edu.tw). We will remove the work from the repository and investigate your claim.
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback