資料載入中.....
|
請使用永久網址來引用或連結此文件:
https://nccur.lib.nccu.edu.tw/handle/140.119/121403
|
| 題名: | Developing and validating a multivariable prediction model to improve the diagnostic accuracy in determination of cervical vs. endometrial origin of uterine adenocarcinomas |
| 作者: | Lin, G;Lin, YC;Wu, RC;Yang, LY;Lu, HY;Tsai, SY;Huang, YT;Huang, YL;Lu, KY;Ng, KK;Yen, TC;Chao, A;Lai, CH;Hong, JH
蔡尚岳
Tsai, Shang‐Yueh |
| 貢獻者: | 應物所 |
| 關鍵詞: | cervical carcinoma;diagnostic accuracy;diffusion-weighted imaging;endometrial carcinoma;magnetic resonance imaging;magnetic resonance spectroscopy |
| 日期: | 2018-06 |
| 上傳時間: | 2018-12-17 15:14:38 (UTC+8) |
| 摘要: | BACKGROUND:A triage test to assist clinical decision-making on choosing primary chemoradiation for cervical carcinomas or primary surgery for endometrial carcinomas is important.PURPOSE OR HYPOTHESIS:To develop and validate a multiparametric prediction model based on MR imaging and spectroscopy in distinguishing adenocarcinomas of uterine cervical or endometrial origin.STUDY TYPE:Prospective diagnostic accuracy study.POPULATION:Eighty-seven women: 25 cervical and 62 endometrial adenocarcinomas divided into training (n = 43; cervical/endometrial adenocarcinomas = 11/32) and validation (n = 44; 14/30) datasets.FIELD STRENGTH/SEQUENCE:The 3T diffusion-weighted (DW) MR imaging and MR spectroscopy.ASSESSMENT:Morphology, volumetric DW MR imaging and spectroscopy (MDS) scoring system with total points 0-5, based on presence of the following MR features assessed independently by two radiologists: (a) epicenter at the cervix, (b) rim enhancement, (c) disrupted cervical stromal integrity, (d) mean volumetric apparent diffusion coefficient values (ADCmean) higher than 0.98 × 10-3 mm2 /s, (e) fatty acyl δ 1.3 ppm more than 161.92 mM. Histopathology as gold standard.STATISTICAL TESTS:Logistic regression and receiver operator characteristic (ROC) curves analysis.RESULTS:For both the training and validation datasets, the MDS score achieved an accuracy of 93.0% and 84.1%, significantly higher than that of morphology (88.4% and 79.5%), ADC value (74.4% and 68.2%), and spectroscopy (81.4% and 68.2%; P < 0.05 for all). The performances of the scoring were superior to the morphology in the training dataset (areas under the receiver operating characteristics curve [AUC] = 0.95 vs. 0.89; P = 0.046), but not in the validation dataset (AUC = 0.90 vs. 0.85; P = 0.289).DATA CONCLUSION:MDS score has potentials to improve distinguishing adenocarcinomas of cervical or endometrial origin, and warrants large-scale studies for further validation. |
| 關聯: | Journal of Magnetic Resonance Imaging, Vol.47, No.6, pp.1654-1666 |
| 資料類型: | article |
| DOI 連結: | http://dx.doi.org/10.1002/jmri.25899 |
| DOI: | 10.1002/jmri.25899 |
| 顯示於類別: | [教育學系] 期刊論文
|
文件中的檔案:
| 檔案 |
描述 |
大小 | 格式 | 瀏覽次數 |
|---|
| index.html | | 0Kb | HTML2 | 702 | 檢視/開啟 |
|
在政大典藏中所有的資料項目都受到原著作權保護.
|
