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https://nccur.lib.nccu.edu.tw/handle/140.119/120101
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| Title: | Effect of Pachybasin on General Toxicity and Developmental Toxicity in Vivo |
| Authors: | Lin, Yi-Ruu;Peng, Kou-Cheng;Chan, Ming-Huan;Peng, Huan-Lin;Liu, Shu-Ying
詹銘煥
Chan, Ming-Huan |
| Contributors: | 神科所 |
| Keywords: | Trichoderma harzianum;developmental toxicity;general toxicity;pachybasin |
| Date: | 2017-12 |
| Issue Date: | 2018-09-17 18:03:18 (UTC+8) |
| Abstract: | To document the safety of pachybasin, a secondary metabolite of Trichoderma harzianum, for use as a bioagricultural agent, it was subjected to general toxicological testing in mice and developmental toxicity in zebrafish. With either 5 or 20 mg kg-1 pachybasin i.p. injection, mice behavioral responses such as motor coordination, spontaneous locomotor activity, or nociceptive pain were not influenced. In long-term effect (daily injection for 14 days), the physiological, hematological, liver, and kidney functions were not altered either. Evidence for the developmental toxicity of pachybasin (10-100 μM) in 72-h exposure period was shown in zebrafish larvae, based on developmental retardation, impairment of chorion, and increase of mortality. In summary, there are no significant general toxicities presented in the pachybasin-treated adult male mice. However, the embryo-toxicity in aquatic biota should be taken into consideration during bioagricultural agent application. |
| Relation: | J. Agric. Food Chem. 65, 48, 10489-10494
PMID: 29111710 |
| Data Type: | article |
| DOI 連結: | https://doi.org/10.1021/acs.jafc.7b03879 |
| DOI: | 10.1021/acs.jafc.7b03879 |
| Appears in Collections: | [神經科學研究所] 期刊論文
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