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| Title: | CRISPR-Cas9基因編輯技術專利之研究- 以BROAD v. UC-Berkley案為例
The study of CRISPR-Cas9 gene editing technology patent- A case study of BROAD v. UC-Berkley |
| Authors: | 張博淳
Chang, Po-Chun |
| Contributors: | 馮震宇
Fong, Jerry G.
張博淳
Chang, Po-Chun |
| Keywords: | 基因編輯
生物技術
生技產業
CRISPR-Cas9
專利衝突
專利聯盟
商業模式
Gene editing
Biotechnology
Biotech industry
CRISPR-Cas9
Interference proceeding
Patent pool
Business model |
| Date: | 2018 |
| Issue Date: | 2018-08-29 15:56:29 (UTC+8) |
| Abstract: | 隨著近代分子生物學及遺傳工程技術不斷發展，科學界已逐步將基因工程提升到基因編輯技術。基因編輯技術可標靶特定DNA序列，並對序列進行基因的剔除及加入，實現對目標基因進行編輯的目的。在現今三大主流基因編輯技術中，CRISPR-Cas9系統因製作簡單且精準度高，被認為是基因編輯技術中最具潛力的一種，因此學術界及產業界也積極發展相關技術及申請專利。
本論文介紹基因編輯技術，整理CRISPR-Cas9發展之歷程，歸納此技術與其他技術之差異及優勢，以及最新的產業應用性及市場預測。CRISPR-Cas9專利兩大領頭羊為Jennifer Doudna領軍的UC-Berkley團隊及美國麻省理工學院張鋒領軍的BROAD研究所團隊。UC於2015年向USPTO提出專利衝突程序，主張BROAD專利與其專利有重複之處，並應予以撤銷。PTAB於2017年作出關鍵決定，認定二者專利並不存在衝突，因此張鋒團隊可保有其專利。本論文在美國專利適格性之最新判斷基準下，針對二者專利請求項進行專利適格性之分析，並討論PTAB對於此案新穎性及非顯而易見性之專利要件審理依據。
PTAB的決定並不代表最終的結果，此案後續發展對於未來學術界乃至於生物技術產業界都有舉足輕重的影響。本論文建議未來應嚴謹審查生物技術專利請求項，免除因訴訟而引發之專利不確定性，延緩產業發展。在商業面上，本論文嘗試整合過去生物技術成功商業化案例關鍵要素及探討BROAD所創建之CRISPR專利聯盟授權模式，以作為此技術未來商業發展及技術推廣之方向。期待CRISPR-Cas9未來進入消費者市場後可提升人類生活品質並創造基因編輯技術之蓬勃發展。
With the continuous development of modern molecular biology and genetic engineering technology, the scientific community has gradually upgraded genetic engineering to gene editing technology. Gene editing technology can target specific DNA sequences, and achieve the purpose of editing target gene by eliminating and adding genes to the sequence. Among the three current major gene editing technologies, CRISPR-Cas9 system is considered to be the most promising of genetic editing technology because of its simplicity and high precision. Therefore, academics and industry are actively developing related technologies and applying patents.
This thesis introduces the development and advantages of CRISPR-Cas9 gene editing, as well as its latest industrial applicability and market forecast. The two leading organizations of CRISPR-Cas9 patent are UC-Berkley team led by Jennifer Doudna and BROAD Institute team led by Zhang Feng of the Massachusetts Institute of Technology. In 2015, UC filed an interference proceeding to USPTO, claiming that BROAD’s patent has interfered with UC’s patent and should be revoked. PTAB made a decision in 2017 and concluded that there is no interfernce-in-fact between two patents, so the Zhang Feng team can retain its patents. Under the latest judgment criteria of US patent eligibility, this paper analyzes the patent eligibility of the two patent claims and discusses the basis for PTAB`s patentability of the novelty and non-obviousness of the case.
The decision of PTAB does not represent the final result. The subsequent development of this case will have a significant impact on the future academic community and even the biotechnology industry. This paper suggests that the biotechnology patent claims should be rigorously reviewed in the future, exempting patent uncertainty caused by litigation and delaying industrial development. On the commercial side, this paper attempts to integrate the key elements of the successful commercialization of biotechnology in the past and discuss the licensing model of CRISPR patent-pool created by BROAD for reference of future business development and technology promotion of this technology. With the future entry of CRISPR-Cas9 to the consumer market, hope it will enhance the quality of human life and create a flourishing development of genetic editing technology. |
| Reference: | 一、中文參考資料
(一)期刊
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二、英文參考資料
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三、網際網路
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| Description: | 碩士
國立政治大學
法學院碩士在職專班
103961030 |
| Source URI: | http://thesis.lib.nccu.edu.tw/record/#G0103961030 |
| Data Type: | thesis |
| DOI: | 10.6814/THE.NCCU.LLME.014.2018.F10 |
| Appears in Collections: | [法學院碩士在職專班] 學位論文
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