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Title:	Simultaneous multi-slice inverse imaging of the human brain
Authors:	蔡尚岳 Hsu, Yi-Cheng Chu, Ying-Hua Tsai, Shang-Yueh Kuo, Wen-Jui Chang, Chun-Yuan
Contributors:	應物所
Date:	2017-12
Issue Date:	2018-04-18 14:45:31 (UTC+8)
Abstract:	(BOLD) signals with high sensitivity and specificity. Here we propose a novel method: simultaneous multi-slice inverse imaging (SMS-InI) — a combination of simultaneous multi-slice excitation, simultaneous echo refocusing (SER), blipped controlled aliasing in parallel imaging echo-planar imaging (EPI), and regularized image reconstruction. Using a 32-channel head coil array on a 3 T scanner, SMS-InI achieves nominal isotropic 5-mm spatial resolution and 10 Hz sampling rate at the whole-brain level. Compared with traditional inverse imaging, we found that SMS-InI has higher spatial resolution with lower signal leakage and higher time-domain signal-to-noise ratio with the optimized regularization parameter in the reconstruction. SMS-InI achieved higher effective resolution and higher detection power in detecting visual cortex activity than InI. SMS-InI also detected subcortical fMRI signals with the similar sensitivity and localization accuracy like EPI. The spatiotemporal resolution of SMS-InI was used to reveal that presenting visual stimuli with 0.2 s latency between left and right visual hemifield led to 0.2 s relative hemodynamic response latency between the left and right visual cortices. Together, these results indicate that SMS-InI is a useful tool in measuring cortical and subcortical hemodynamic responses with high spatiotemporal resolution.
Relation:	Scientific Reports, 2017; 7: 17019.
Data Type:	article
DOI link:	https://dx.doi.org/10.1038%2Fs41598-017-16976-0
DOI:	10.1038/s41598-017-16976-0
Appears in Collections:	[Graduate Institute of Applied Physics] Periodical Articles

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