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    政大機構典藏 > 理學院 > 心理學系 > 期刊論文 >  Item 140.119/113034


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    題名: New perspectives of biomarkers for the management of chronic hepatitis B
    作者: Lin, Chih Lin
    Kao, Jia Horng
    貢獻者: 心理系
    關鍵詞: biological marker;cotransporter;hepatitis B surface antigen;hepatitis B(e) antigen;organic anion transporter;sodium-bile acid cotransporter;virus DNA;blood;complication;genetics;Hepatitis B virus;Hepatitis B, Chronic;human;liver cirrhosis;risk factor;single nucleotide polymorphism;Biomarkers;DNA, Viral;Hepatitis B e Antigens;Hepatitis B Surface Antigens;Hepatitis B virus;Hepatitis B, Chronic;Humans;Liver Cirrhosis;Organic Anion Transporters, Sodium-Dependent;Polymorphism, Single Nucleotide;Risk Factors;Symporters
    日期: 2016-12
    上傳時間: 2017-09-15 15:19:07 (UTC+8)
    摘要: With recent advances in molecular and genomic investigations, the impact of hepatitis B viral and host factors on the progression of chronic HBV infection has been explored. For viral factors, hepatitis B viral load is a strong predictor for liver disease progression. Hepatitis B viral kinetics appear to be important for successful anti-viral therapy. Serum HBsAg level serves as a complementary marker to viral load for the prediction of HBV-related adverse outcomes in patients with low viral load. In those with low viral load, high serum HBsAg level is associated with higher risks of cirrhosis and HCC. Hepatitis B core-related antigen (HBcrAg) induces host immune responses, and the reduction of the HBcrAg level as well as the increment of total anti-HBc level are significantly associated with favorable outcomes. HBV genotypes (genotype C/D) and mutants (basal core promoter and deletion mutation in pre-S genes) are well known viral genetic markers to predict disease progression. For host factors, serum inflammatory biomarkers have been developed to evaluate the HBV-associated hepatic necroinflammation and fibrosis. Host single nucleotide polymorphism on sodium taurocholate cotransporting polypeptide (NTCP, an HBV entry receptor) may be associated with a decreased risk for cirrhosis and HCC. In conclusion, patients with chronic hepatitis B should be evaluated with relevant viral and host markers to identify those who are at a higher risk of liver disease progression and then receive timely antiviral therapy.
    關聯: Clinical and molecular hepatology, 22(4), 423-431
    資料類型: article
    DOI 連結: http://dx.doi.org/10.3350/cmh.2016.0069
    DOI: 10.3350/cmh.2016.0069
    顯示於類別:[心理學系] 期刊論文

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