English  |  正體中文  |  简体中文  |  Post-Print筆數 : 27 |  Items with full text/Total items : 113648/144635 (79%)
Visitors : 51626164      Online Users : 555
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version
    政大機構典藏 > 理學院 > 心理學系 > 期刊論文 >  Item 140.119/113034


    Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/113034


    Title: New perspectives of biomarkers for the management of chronic hepatitis B
    Authors: Lin, Chih Lin
    Kao, Jia Horng
    Contributors: 心理系
    Keywords: biological marker;cotransporter;hepatitis B surface antigen;hepatitis B(e) antigen;organic anion transporter;sodium-bile acid cotransporter;virus DNA;blood;complication;genetics;Hepatitis B virus;Hepatitis B, Chronic;human;liver cirrhosis;risk factor;single nucleotide polymorphism;Biomarkers;DNA, Viral;Hepatitis B e Antigens;Hepatitis B Surface Antigens;Hepatitis B virus;Hepatitis B, Chronic;Humans;Liver Cirrhosis;Organic Anion Transporters, Sodium-Dependent;Polymorphism, Single Nucleotide;Risk Factors;Symporters
    Date: 2016-12
    Issue Date: 2017-09-15 15:19:07 (UTC+8)
    Abstract: With recent advances in molecular and genomic investigations, the impact of hepatitis B viral and host factors on the progression of chronic HBV infection has been explored. For viral factors, hepatitis B viral load is a strong predictor for liver disease progression. Hepatitis B viral kinetics appear to be important for successful anti-viral therapy. Serum HBsAg level serves as a complementary marker to viral load for the prediction of HBV-related adverse outcomes in patients with low viral load. In those with low viral load, high serum HBsAg level is associated with higher risks of cirrhosis and HCC. Hepatitis B core-related antigen (HBcrAg) induces host immune responses, and the reduction of the HBcrAg level as well as the increment of total anti-HBc level are significantly associated with favorable outcomes. HBV genotypes (genotype C/D) and mutants (basal core promoter and deletion mutation in pre-S genes) are well known viral genetic markers to predict disease progression. For host factors, serum inflammatory biomarkers have been developed to evaluate the HBV-associated hepatic necroinflammation and fibrosis. Host single nucleotide polymorphism on sodium taurocholate cotransporting polypeptide (NTCP, an HBV entry receptor) may be associated with a decreased risk for cirrhosis and HCC. In conclusion, patients with chronic hepatitis B should be evaluated with relevant viral and host markers to identify those who are at a higher risk of liver disease progression and then receive timely antiviral therapy.
    Relation: Clinical and molecular hepatology, 22(4), 423-431
    Data Type: article
    DOI 連結: http://dx.doi.org/10.3350/cmh.2016.0069
    DOI: 10.3350/cmh.2016.0069
    Appears in Collections:[心理學系] 期刊論文

    Files in This Item:

    File Description SizeFormat
    431.pdf748KbAdobe PDF2329View/Open


    All items in 政大典藏 are protected by copyright, with all rights reserved.


    社群 sharing

    著作權政策宣告 Copyright Announcement
    1.本網站之數位內容為國立政治大學所收錄之機構典藏，無償提供學術研究與公眾教育等公益性使用，惟仍請適度，合理使用本網站之內容，以尊重著作權人之權益。商業上之利用，則請先取得著作權人之授權。
    The digital content of this website is part of National Chengchi University Institutional Repository. It provides free access to academic research and public education for non-commercial use. Please utilize it in a proper and reasonable manner and respect the rights of copyright owners. For commercial use, please obtain authorization from the copyright owner in advance.

    2.本網站之製作，已盡力防止侵害著作權人之權益，如仍發現本網站之數位內容有侵害著作權人權益情事者，請權利人通知本網站維護人員(nccur@nccu.edu.tw)，維護人員將立即採取移除該數位著作等補救措施。
    NCCU Institutional Repository is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff(nccur@nccu.edu.tw). We will remove the work from the repository and investigate your claim.
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback