English  |  正體中文  |  简体中文  |  Post-Print筆數 : 27 |  Items with full text/Total items : 113656/144643 (79%)
Visitors : 51713364      Online Users : 295
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version


    Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/112472


    Title: Contrasting variability patterns in the default mode and sensorimotor networks balance in bipolar depression and mania
    Authors: Martino, Matteo
    Magioncalda, Paola
    Huang, Zi Rui
    Conio, Benedetta
    Piaggio, Niccolò
    Northoff, Georg
    Contributors: 心智、大腦與學習研究中心
    Keywords: anterior cingulate;bipolar depression;BOLD signal;cingulate gyrus;clinical article;conference;controlled study;default mode network;electroencephalogram;follow up;Hamilton Depression Rating Scale;human;inferior parietal lobule;mania;medial prefrontal cortex;middle frontal gyrus;middle temporal gyrus;nerve cell network;neuroimaging;postcentral gyrus;posterior cingulate;potential difference;priority journal;replication study;resting state network;sensorimotor function;Young Mania Rating Scale;adolescent;adult;affect;bipolar disorder;blood;brain mapping;comparative study;female;male;middle aged;movement (physiology);nerve cell network;nuclear magnetic resonance imaging;pathophysiology;physiology;psychology;rest;restlessness;sensation;thinking;young adult;oxygen;Adolescent;Adult;Affect;Bipolar Disorder;Brain Mapping;Female;Humans;Magnetic Resonance Imaging;Male;Middle Aged;Movement;Nerve Net;Oxygen;Psychomotor Agitation;Rest;Sensation;Thinking;Young Adult
    Date: 2016-04
    Issue Date: 2017-08-31 15:00:01 (UTC+8)
    Abstract: Depressive and manic phases in bipolar disorder show opposite constellations of affective, cognitive, and psychomotor symptoms. At a neural level, these may be related to topographical disbalance between large-scale networks, such as the default mode network (DMN) and sensorimotor network (SMN). We investigated topographical patterns of variability in the resting-state signal-measured by fractional SD (fSD) of the BOLD signal-of the DMN and SMN (and other networks) in two frequency bands (Slow5 and Slow4) with their ratio and clinical correlations in depressed (n = 20), manic (n = 20), euthymic (n = 20) patients, and healthy controls (n = 40). After controlling for global signal changes, the topographical balance between the DMN and SMN, specifically in the lowest frequency band, as calculated by the Slow5 fSD DMN/SMN ratio, was significantly increased in depression, whereas the same ratio was significantly decreased in mania. Additionally, Slow5 variability was increased in the DMN and decreased in the SMN in depressed patients, whereas the opposite topographical pattern was observed in mania. Finally, the Slow5 fSD DMN/SMN ratio correlated positively with clinical scores of depressive symptoms and negatively with those of mania. Results were replicated in a smaller independent bipolar disorder sample.We demonstrated topographical abnormalities in frequency- specific resting-state variability in the balance between DMN and SMN with opposing patterns in depression and mania. The Slow5 DMN/SMN ratio was tilted toward the DMN in depression but was shifted toward the SMN in mania. The Slow5 fSD DMN/SMN pattern could constitute a state-biomarker in diagnosis and therapy.
    Relation: Proceedings of the National Academy of Sciences of the United States of America, 113(17), 4824-4829
    Data Type: conference
    DOI 連結: http://dx.doi.org/10.1073/pnas.1517558113
    DOI: 10.1073/pnas.1517558113
    Appears in Collections:[心智‧大腦與學習研究中心 ] 會議論文

    Files in This Item:

    File Description SizeFormat
    4829.pdf1100KbAdobe PDF2584View/Open


    All items in 政大典藏 are protected by copyright, with all rights reserved.


    社群 sharing

    著作權政策宣告 Copyright Announcement
    1.本網站之數位內容為國立政治大學所收錄之機構典藏，無償提供學術研究與公眾教育等公益性使用，惟仍請適度，合理使用本網站之內容，以尊重著作權人之權益。商業上之利用，則請先取得著作權人之授權。
    The digital content of this website is part of National Chengchi University Institutional Repository. It provides free access to academic research and public education for non-commercial use. Please utilize it in a proper and reasonable manner and respect the rights of copyright owners. For commercial use, please obtain authorization from the copyright owner in advance.

    2.本網站之製作，已盡力防止侵害著作權人之權益，如仍發現本網站之數位內容有侵害著作權人權益情事者，請權利人通知本網站維護人員(nccur@nccu.edu.tw)，維護人員將立即採取移除該數位著作等補救措施。
    NCCU Institutional Repository is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff(nccur@nccu.edu.tw). We will remove the work from the repository and investigate your claim.
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback