 |
English
|
正體中文
|
简体中文
|
Post-Print筆數 : 27 |
Items with full text/Total items : 113656/144643 (79%)
Visitors : 51713354
Online Users : 295
|
|
|
Loading...
|
Please use this identifier to cite or link to this item:
https://nccur.lib.nccu.edu.tw/handle/140.119/112327
|
| Title: | Cerebral blood flow autoregulation is impaired in schizophrenia: A pilot study |
| Authors: | 藍亭
Ku, Hsiao Lun
Wang, Jiunn Kae
Lee, Hsin Chien
Lane, Timothy Joseph
Liu, I. Chao
Chen, Yung Chan
Lee, Yao Tung
Lin, I. Cheng
Lin, Chia Pei
Hu, Chaur Jongh
Chi, Nai Fang |
| Contributors: | 心智、大腦與學習研究中心 |
| Keywords: | Cerebral autoregulation;Cerebral blood flow;Cerebrovascular diseases;Schizophrenia |
| Date: | 2017-01 |
| Issue Date: | 2017-08-31 11:23:00 (UTC+8) |
| Abstract: | Patients with schizophrenia have a higher risk of cardiovascular diseases and higher mortality from them than does the general population; however, the underlying mechanism remains unclear. Impaired cerebral autoregulation is associated with cerebrovascular diseases and their mortality. Increased or decreased cerebral blood flow in different brain regions has been reported in patients with schizophrenia, which implies impaired cerebral autoregulation. This study investigated the cerebral autoregulation in 21 patients with schizophrenia and 23 age- and sex-matched healthy controls. None of the participants had a history of cardiovascular diseases, hypertension, or diabetes. All participants underwent 10-min blood pressure and cerebral blood flow recording through finger plethysmography and Doppler ultrasonography, respectively. Cerebral autoregulation was assessed by analyzing two autoregulation indices: the mean blood pressure and cerebral blood flow correlation coefficient (Mx), and the phase shift between the waveforms of blood pressure and cerebral blood flow determined using transfer function analysis. Compared with the controls, the patients had a significantly higher Mx (0.257 vs. 0.399, p = 0.036) and lower phase shift (44.3° vs. 38.7° in the 0.07-0.20. Hz frequency band, p = 0.019), which indicated impaired maintenance of constant cerebral blood flow and a delayed cerebrovascular autoregulatory response. Impaired cerebral autoregulation may be caused by schizophrenia and may not be an artifact of coexisting medical conditions. The mechanism underlying impaired cerebral autoregulation in schizophrenia and its probable role in the development of cerebrovascular diseases require further investigation. |
| Relation: | Schizophrenia Research |
| Data Type: | article |
| DOI 連結: | http://dx.doi.org/10.1016/j.schres.2017.01.015 |
| DOI: | 10.1016/j.schres.2017.01.015 |
| Appears in Collections: | [心智‧大腦與學習研究中心 ] 期刊論文
|
Files in This Item:
| File |
Description |
Size | Format | |
|---|
| 1-5.pdf | | 419Kb | Adobe PDF2 | 591 | View/Open |
|
All items in 政大典藏 are protected by copyright, with all rights reserved.
|
著作權政策宣告 Copyright Announcement1.本網站之數位內容為國立政治大學所收錄之機構典藏，無償提供學術研究與公眾教育等公益性使用，惟仍請適度，合理使用本網站之內容，以尊重著作權人之權益。商業上之利用，則請先取得著作權人之授權。
The digital content of this website is part of National Chengchi University Institutional Repository. It provides free access to academic research and public education for non-commercial use. Please utilize it in a proper and reasonable manner and respect the rights of copyright owners. For commercial use, please obtain authorization from the copyright owner in advance.
2.本網站之製作，已盡力防止侵害著作權人之權益，如仍發現本網站之數位內容有侵害著作權人權益情事者，請權利人通知本網站維護人員(
nccur@nccu.edu.tw)，維護人員將立即採取移除該數位著作等補救措施。
NCCU Institutional Repository is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff(
nccur@nccu.edu.tw). We will remove the work from the repository and investigate your claim.
