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    Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/108121


    Title: 以MEGA-PRESS頻譜編輯技術偵測大腦乳酸 及探討平均頻譜次數與擬合參數之影響
    The detection of lactate in human brain using MEGA-PRESS spectral editing technique and the affect between times of average spectrum and fitting parameters
    Authors: 粘政緯
    Nien, Cheng Wei
    Contributors: 蔡尚岳
    Tsai, Shang Yueh
    粘政緯
    Nien, Cheng Wei
    Keywords: 磁共振頻譜
    耦合
    MEGA-PRESS
    Date: 2017
    Issue Date: 2017-04-05 15:37:10 (UTC+8)
    Abstract: 乳酸(Lactate)是一種人體內常見的代謝物，也是無氧代謝後的最終產物。人體在運動過後血液中的乳酸濃度會上升，但在一般情況下大腦中的乳酸含量非常低，正常人腦乳酸濃度約低於0.5毫莫耳(mM)，由於腦乳酸的低濃度，以及在磁共振頻譜中的乳酸訊號與大分子(macromolecular)部分訊號重疊，導致在正常大腦中不易得到乳酸的頻譜訊號。近年來，有文獻指出在3T的磁場下利用MEGA-PRESS技術可以量測到乳酸在大腦經由低氧與高氧交替過程中的改變，而Mescher-Garwood(MAGA) point-resolved spectroscopy sequence(PRESS)頻譜編輯技術是由原本的PRESS脈衝序列再增加兩個選擇性的脈衝，透過頻譜相減消除不具有J-耦合特性的代謝物，來針對具有J-耦合特性的代謝物訊號做測量。本研究的目的為在3T的磁場下，利用MEGA-PRESS技術量到乳酸的頻譜訊號之外，再藉由不同的擬合(fitting)方式以及處理頻譜平均次數來得到不同條件下乳酸頻譜的標準差及變異係數值，以衡量利用在視覺刺激下是否能得到大腦視覺區中乳酸的改變差異，並提供一份乳酸對擬合參數的改變及平均次數多寡的參考依據。
    Reference: [1] M.Mescher, H.Merkle, J.Kirsch,M.Garwood, and R.Gruetter, "Simultaneous in vivo spectral editing and water suppression,"NMR in Biomedicine,vol.11, pp.266-272,1998.

    [2] Richard A.E.Edden, Ashley D.Harris, and Kevin Murphy,"Edited MRS is sensitive to changes in lactate concentration during inspiratory hypoxia,"(2010)

    [3] Yan Lin, Mary C Stephenson, and Lijing Xin, "Investigating the metabolic changes due to visual stimulation using functional proton magnetic resonance spectroscopy at 7T,"(2012)

    [4] Ashley D.Harris, Victoria H.Roberton, and Danielle L.Huckle, "Temporal dynamics of Lactate concentration in the human brain during acute inspiratory hypoxia,"(2013)

    [5] Jaime M.Ross, Johanna Öberg, and Stefan Brené, "High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio,"(2010)

    [6] D.Lau, N.Klein, and B.Cunha, "Brain abscess mimisking brain tumor," Heart & Lung：the journal of critical care,vol.18,pp.634-637,1989

    [7] V.Govindaraju,K.Young,and A.A.Maudsley,"Proton NMR chemical shifts and constant for brain metabolites,"NMR in Biomedicine,vol.13,pp.129-153,2000.


    [8] Sean Hansen-Romu, "Simulation of the Ultra-Cold Neutron Spin Analyzer Foil." ,p14,(2015)

    [9] 陳志宏、張允中和謝昭賢等編著。第15 章核磁共振與磁振造影 "Nuclear Magnetic
    Resonanceand Magnetic Resonance Imaging", p10.

    [10] Ray H. Hashemi, William G. Bradley, Christopher J. Lisanti. "MRI the basics." Lippincott Williams & Wilkins (2004).

    [11] Robin A. de Graaf. "In Vivo NMR Spectroscopy" 2nd Edition , John
    Wiley & Sons, Ltd (2007)
    Description: 碩士
    國立政治大學
    應用物理研究所
    103755014
    Source URI: http://thesis.lib.nccu.edu.tw/record/#G0103755014
    Data Type: thesis
    Appears in Collections:[Graduate Institute of Applied Physics] Theses

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