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| Title: | 阿朴嗎啡對中樞神經激胺的影響
Effects of apomorphine on central serotonergic system |
| Authors: | 王豐彬
Wang, Feng-Bin |
| Contributors: | 李小媛
Li, Xiao-Yuan
王豐彬
Wang, Feng-Bin |
| Keywords: | 心理學
PSYCHIATRY
PSYCHOLOGY |
| Date: | 1984 |
| Issue Date: | 2016-05-05 17:24:27 (UTC+8) |
| Abstract: | 以高壓液態色層分析(HPLC)螢光測定生化分析同時量測背側縫合核及紋狀體中Tryp
序言 壹
論文摘要 參
第一章 導論1
第一節 文獻探討1
第二節 研究目的8
第二章 研究方法11
第一節 實驗動物11
第二節 藥品11
第三節 儀器設備－－HPLC介紹 12
第四節 手術－－腦部注射14
第五節 組織切取20
第六節 統計方法21
第三章 實驗與結果23
第一節 APO對5-HT影響的詳細藥理機構23
第二節 紋狀體DA突觸前接受器在APO對5-HT影響上所扮演的角色24
第三節 GABA在APO對5-HT影響中可能扮演的角色34
第四章 討論49
第一節 APO對5-HT影響的詳細藥理機構49
第二節 紋狀體DA突觸前接受器在APO對5-HT影響上所扮演的角色50
第三節 GABA在APO對5-HT影響中可能扮演的角色52
第四節 APO對5-HT影響的行為含意53
第五章 結論55
參考文獻57
名詞對照表67
圖表目次
圖一 簡易神經通路4
圖二 外在標準的HPLC螢光測定生化分析圖15
圖三 背側縫合核的HPLC螢光測定生化分析圖16
圖四 尾狀核的HPLC螢光測定生化分析圖17
圖五 腹側縫合核的HPLC螢光測定生化分析圖18
圖六 海馬迴的HPLC螢光測定生化分析圖19
Table 1. Effects of apomorphine (3.0mg/kg, i.p.) on monoamine neurotransmitters and their precursors in dorsal raphe 25
Table 2. Effects of apomorphine (3.0mg/kg, i.p.) on monoamine neurotransmitters and their precursors in caudate 26
Table 3. Effects of apomorphine (3.0mg/kg, i.p.) on monoamine neurotransmitters and their precursors in median raphe. 27
Table 4. Effects of apomorphine (3.0mg/kg, i.p.) on monoamine neurotransmitters and their precursors in hippocarnpus. 28
Table 5. Effects of 7 days 6-hydroxydopamine (caudate) and apomorphine (3.0mg/kg, i.p.) on monoamine neurotransmitters and their precursors in dorsal raphe. 31
Table 6. Effects of 7 days 6-hydroxydopamine (caudate) and apomorphine (3.0mg/kg, i.p.) on monoamine neurotransmitters and their precursors in caudate. 32
Table 7. Effects of 7 days 6-hydroxydopamine (caudate) and apomorphine (3.0mg/kg, i.p.) on monoamine neurotransmitters and their precursors in median raphe. 35
Table 8 Effects of 7 days 6-hydroxydopamine (caudate) and apomorphine (3.0mg/kg, i.p.) on monoamine neurotransmitters and their precursors in hippocampus. 36
Table 9. Effects of apomorphine infusion (5ug,caudate) on monoamine neurotransmitters and their precursors in dorsal raphe. 37
Table 10. Effects of apomorphine infusion (5ug,caudate) on monoamine neurotransmitters and their precursors in caudate. 38
Table 11. Effects of apomorphine infusion (8ug,caudate) on monoamine neurotransmitters and their precursors in dorsal raphe. 39
Table 12. Effects of apomorphine infusion (8ug,caudate) on monoamine neurotransmitters and their precursors in caudate. 40
Table 13. Effects of apomorphine (8ug,caudate) on monoamine neurotransmitters and their precursors in mdeian raphe. 41
Table 14. Effects of apomorphine (8ug,caudate) on monoamine neurotransmitters and their precursors in hippocampus. 42
Table 15. Effects of apomorphine (3.0mg/kg, i.p.)
and picrotoxin (4mg/kg, i.p.) on monoamine neurotransmitters and their precursors in dorsal raphe. 45
Table 16. Effects of apomorphine (3.0mg/kg, i.p.) and picrotoxin (4mg/kg, i.p.) on monoamine neurotransmitters and their precursors in caudate. 46
Table 17. Effects of apomorphine (3.0mg/kg, i.p.) and picrotoxin (4mg/kg, i.p.) on monoamine neurotransmitters and their precursors in median raphe. 47
Table 18. Effects of apomorphine (3.0mg/kg, i.p.) and picrotoxin (4mg/kg, i.p.) on monoamine neurotransmitters and their precursors in hippocampus. 48
附圖：Histology：Dye (Methylene Blue, 3mg/ml) infusion to caudate Neutral Red Staining. 65 |
| Description: | 碩士
國立政治大學
心理學系 |
| Source URI: | http://thesis.lib.nccu.edu.tw/record/#B2002007106 |
| Data Type: | thesis |
| Appears in Collections: | [心理學系] 學位論文
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