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    题名: T-Coffee: a web server for the multiple sequence alignment of protein and RNA sequences using structural information and homology extension
    作者: Chang, Jia-Ming
    張家銘
    Notredame, Cedric
    Taly, Jean-François
    Montanyola, Alberto
    Orobitg, Miquel
    Xenarios, Ioannis
    Moretti, Sebastien
    Tommaso, Di;Paolo
    贡献者: 資科系
    日期: 2011-07
    上传时间: 2016-04-27 15:29:56 (UTC+8)
    摘要: This article introduces a new interface for T-Coffee, a consistency-based multiple sequence alignment program. This interface provides an easy and intuitive access to the most popular functionality of the package. These include the default T-Coffee mode for protein and nucleic acid sequences, the M-Coffee mode that allows combining the output of any other aligners, and template-based modes of T-Coffee that deliver high accuracy alignments while using structural or homology derived templates. These three available template modes are Expresso for the alignment of protein with a known 3D-Structure, R-Coffee to align RNA sequences with conserved secondary structures and PSI-Coffee to accurately align distantly related sequences using homology extension. The new server benefits from recent improvements of the T-Coffee algorithm and can align up to 150 sequences as long as 10,000 residues and is available from both http://www.tcoffee.org and its main mirror http://tcoffee.crg.cat.
    關聯: Nucleic Acids Research, 39, W13-17
    数据类型: article
    DOI 連結: http://dx.doi.org/10.1093/nar/gkr245
    DOI: 10.1093/nar/gkr245
    显示于类别:[資訊科學系] 期刊論文

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