 |
English
|
正體中文
|
简体中文
|
Post-Print筆數 : 27 |
Items with full text/Total items : 113648/144635 (79%)
Visitors : 51579674
Online Users : 1063
|
|
|
Loading...
|
Please use this identifier to cite or link to this item:
https://nccur.lib.nccu.edu.tw/handle/140.119/79588
|
| Title: | Tablet splitting of narrow therapeutic index drugs: a nationwide survey in Taiwan |
| Authors: | Chou, Chia-Lin;Hsu, Chia-Chen;Chou, Chia-Yu;Chen, Tzeng-Ji;Chou, Li-Fang;Chou, Yueh-Ching
周麗芳 |
| Contributors: | 財政系 |
| Keywords: | Narrow therapeutic index drugs;Prescribing patterns;Splitting frequency;Tablet splitting;Taiwan |
| Date: | 2015-12 |
| Issue Date: | 2015-12-03 17:46:36 (UTC+8) |
| Abstract: | Background Tablet splitting or pill splitting frequently occurs in daily medical practice. For drugs with special pharmacokinetic characters, such as drugs with narrow therapeutic index (NTI), unequal split tablets might lead to erroneous dose titration and it even cause toxicity. Objective The aim of this study was to investigate the frequency of prescribing split NTI drugs at ambulatory setting in Taiwan. Setting A population-based retrospective study was conducted using the National Health Insurance Research Database in Taiwan. All ambulatory visits were analyzed from the longitudinal cohort datasets of the National Health Insurance Research Database. Methods The details of ambulatory prescriptions containing NTI drugs were extracted by using the claims datasets of one million beneficiaries from National Healthcare Insurance Research Database in 2010 in Taiwan. The analyses were stratified by dosage form, patient age and the number of prescribed tablets in a single dose for each NTI drugs. Main outcome measures Number and distinct dosage forms of available NTI drug items in Taiwan, number of prescriptions involved split NTI drugs, and number of patients received split NTI drugs. Results A total of 148,548 patients had received 512,398 prescriptions of NTI drugs and 41.8 % (n = 62,121) of patients had received 36.3 % (n = 185,936) of NTI drug prescriptions in form of split tablets. The percentage of splitting was highest in digoxin prescriptions (81.0 %), followed by warfarin (72.0 %). In the elderly patients, split tablets were very prevalent with digoxin (82.4 %) and warfarin (84.5 %). Conclusion NTI drugs were frequently prescribed to be taken in split forms in Taiwan. Interventions may be needed to provide effective and convenient NTI drug use. Further studies are needed to evaluate the clinical outcome of inappropriate split NTI drugs. |
| Relation: | International Journal of Clinical Pharmacy, 37(6), 1235-1241 |
| Data Type: | article |
| DOI 連結: | http://dx.doi.org/10.1007/s11096-015-0194-0 |
| DOI: | 10.1007/s11096-015-0194-0 |
| Appears in Collections: | [財政學系] 期刊論文
|
Files in This Item:
| File |
Description |
Size | Format | |
|---|
| 1235-1241.pdf | | 365Kb | Adobe PDF2 | 715 | View/Open |
|
All items in 政大典藏 are protected by copyright, with all rights reserved.
|
著作權政策宣告 Copyright Announcement1.本網站之數位內容為國立政治大學所收錄之機構典藏，無償提供學術研究與公眾教育等公益性使用，惟仍請適度，合理使用本網站之內容，以尊重著作權人之權益。商業上之利用，則請先取得著作權人之授權。
The digital content of this website is part of National Chengchi University Institutional Repository. It provides free access to academic research and public education for non-commercial use. Please utilize it in a proper and reasonable manner and respect the rights of copyright owners. For commercial use, please obtain authorization from the copyright owner in advance.
2.本網站之製作，已盡力防止侵害著作權人之權益，如仍發現本網站之數位內容有侵害著作權人權益情事者，請權利人通知本網站維護人員(
nccur@nccu.edu.tw)，維護人員將立即採取移除該數位著作等補救措施。
NCCU Institutional Repository is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff(
nccur@nccu.edu.tw). We will remove the work from the repository and investigate your claim.
