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    題名: Quantitative and functional interrogation of parent-of-origin allelic expression biases in the brain
    作者: JD, Perez;ND, Rubinstein;DE, Fernandez;SW, Santoro;LA, Needleman;O, Ho-Shing;JJ, Choi;Zirlinger, M;Chen, Shau-Kwaun;Liu, JS;Dulac, C
    陳紹寬
    貢獻者: 神科所
    關鍵詞: Bcl-x;RNA-seq;apoptosis;cerebellum;genomic imprinting;molecular neuroscience;mouse;neuroscience
    日期: 2015-07
    上傳時間: 2015-12-03 17:46:23 (UTC+8)
    摘要: The maternal and paternal genomes play different roles in mammalian brains as a result of genomic imprinting, an epigenetic regulation leading to differential expression of the parental alleles of some genes. Here we investigate genomic imprinting in the cerebellum using a newly developed Bayesian statistical model that provides unprecedented transcript-level resolution. We uncover 160 imprinted transcripts, including 41 novel and independently validated imprinted genes. Strikingly, many genes exhibit parentally biased--rather than monoallelic--expression, with different magnitudes according to age, organ, and brain region. Developmental changes in parental bias and overall gene expression are strongly correlated, suggesting combined roles in regulating gene dosage. Finally, brain-specific deletion of the paternal, but not maternal, allele of the paternally-biased Bcl-x, (Bcl2l1) results in loss of specific neuron types, supporting the functional significance of parental biases. These findings reveal the remarkable complexity of genomic imprinting, with important implications for understanding the normal and diseased brain.
    關聯: Elife, 4, e07860
    資料類型: article
    DOI 連結: http://dx.doi.org/10.7554/eLife.07860
    DOI: 10.7554/eLife.07860
    顯示於類別:[神經科學研究所] 期刊論文

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