政大機構典藏-National Chengchi University Institutional Repository(NCCUR):Item 140.119/79419

English | 正體中文 | 简体中文 | Post-Print筆數 : 27 | Items with full text/Total items : 113648/144635 (79%)
Visitors : 51585658 Online Users : 846

RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.

Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer

政大機構典藏 > 商學院 > 統計學系 > 期刊論文 > Item 140.119/79419

Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/79419

Title:	Reduced Gut Acidity Induces an Obese-Like Phenotype in Drosophila melanogaster and in Mice
Authors:	Lin, Wei-Sheng;Huang, Cheng-Wen;Song, You-Sheng;Yen, Jui-Hung;Kuo, Ping-Chang;Yeh, Sheng-Rong;Lin, Hung-Yu;Fu, Tsai-Feng;Wu, Ming-Shiang;Wang, Horng-Dar;Wang, Pei-Yu 江振東
Contributors:	統計系
Date:	2015-10
Issue Date:	2015-11-25 16:35:57 (UTC+8)
Abstract:	In order to identify genes involved in stress and metabolic regulation, we carried out a Drosophila P-element-mediated mutagenesis screen for starvation resistance. We isolated a mutant, m2, that showed a 23% increase in survival time under starvation conditions. The P-element insertion was mapped to the region upstream of the vha16-1 gene, which encodes the c subunit of the vacuolar-type H+-ATPase. We found that vha16-1 is highly expressed in the fly midgut, and that m2 mutant flies are hypomorphic for vha16-1 and also exhibit reduced midgut acidity. This deficit is likely to induce altered metabolism and contribute to accelerated aging, since vha16-1 mutant flies are short-lived and display increases in body weight and lipid accumulation. Similar phenotypes were also induced by pharmacological treatment, through feeding normal flies and mice with a carbonic anhydrase inhibitor (acetazolamide) or proton pump inhibitor (PPI, lansoprazole) to suppress gut acid production. Our study may thus provide a useful model for investigating chronic acid suppression in patients.
Relation:	PLoS One, 10(10), e0139722
Data Type:	article
DOI 連結:	http://dx.doi.org/10.1371/journal.pone.0139722
DOI:	10.1371/journal.pone.0139722
Appears in Collections:	[統計學系] 期刊論文

Files in This Item:

File	Description	Size	Format
e0139722.pdf		1142Kb	Adobe PDF2	751	View/Open

社群 sharing

著作權政策宣告 Copyright Announcement

1.本網站之數位內容為國立政治大學所收錄之機構典藏，無償提供學術研究與公眾教育等公益性使用，惟仍請適度，合理使用本網站之內容，以尊重著作權人之權益。商業上之利用，則請先取得著作權人之授權。
The digital content of this website is part of National Chengchi University Institutional Repository. It provides free access to academic research and public education for non-commercial use. Please utilize it in a proper and reasonable manner and respect the rights of copyright owners. For commercial use, please obtain authorization from the copyright owner in advance.

2.本網站之製作，已盡力防止侵害著作權人之權益，如仍發現本網站之數位內容有侵害著作權人權益情事者，請權利人通知本網站維護人員(nccur@nccu.edu.tw)，維護人員將立即採取移除該數位著作等補救措施。
NCCU Institutional Repository is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff(nccur@nccu.edu.tw). We will remove the work from the repository and investigate your claim.

Loading...