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Please use this identifier to cite or link to this item:
https://nccur.lib.nccu.edu.tw/handle/140.119/77425
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| Title: | Host genetic variants and hepatitis B virologic features in HBeAg-negative hepatitis B carriers with long-term biochemical remission |
| Authors: | Lin, Chih-Lin
林志陵
Tseng, Tai-Chung
Su, Tung-Hung
Liu, Chun-Jen
Chen, Pei-Jer
Lai, Ming-Yang
Chen, Ding-Shinn
Kao, Jia-Horng |
| Contributors: | 心理學系 |
| Keywords: | HBeAg-negative carrier;Hepatitis B virus;HBV-DNA;Alanine aminotransferase;Host genetic variants |
| Date: | 2012-06 |
| Issue Date: | 2015-08-05 14:36:54 (UTC+8) |
| Abstract: | Purpose:A significant portion of HBeAg-negative chronic hepatitis B patients have persistently normal serum alanine aminotransferase levels (PNALT). We thus investigated host genetic variants and virological features in HBeAg-negative hepatitis B carriers.Methods:Baseline clinical and virological features of 133 HBeAg-negative hepatitis B carriers (77 with PNALT and 56 with chronic hepatitis activity) with follow-up for more than 5 years were investigated. Three single nucleotide polymorphisms (SNPs) located within or around human leukocyte antigen (HLA)-DPA1, HLA-DPB1, and interleukin (IL) 28B loci were genotyped.Results:The genotype frequencies of these SNPs were comparable between hepatitis B carriers with PNALT and those with chronic hepatitis. Compared with hepatitis B carriers with PNALT, those with chronic hepatitis had significantly higher baseline serum HBV-DNA levels (4.96 vs. 4.04 log10 IU/ml, P = 0.001). Baseline serum HBV-DNA level > 2000 IU/ml (OR, 8.42; 95% CI, 2.74–25.90, P < 0.001) were the only independent factor associated with chronic hepatitis activity. Changes of serum HBV-DNA in 30 hepatitis B carriers with PNALT had showed a significant reduction of viral load from baseline to last visit (mean difference of paired HBV-DNA levels: −0.78 log10 IU/ml, 95% CI: −1.57 to −0.013, P = 0.047). In contrast, no significant reduction of viral load was found in 28 patients with chronic hepatitis.Conclusions:The results indicate that lower baseline serum HBV-DNA level and viral load reduction over time are associated with long-term biochemical remission in HBeAg-negative hepatitis B carriers. |
| Relation: | Hepatology International,6,(3),598-605 |
| Data Type: | article |
| DOI 連結: | http://dx.doi.org/10.1007/s12072-011-9297-4 |
| DOI: | 10.1007/s12072-011-9297-4 |
| Appears in Collections: | [心理學系] 期刊論文
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| 598-605.pdf | | 195Kb | Adobe PDF2 | 822 | View/Open |
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