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    題名: Semantic memory deficits in low-educated patients with Alzheimer`s disease
    作者: Yang, C.-C.;Hua, M.-S.;Chiu, M.-J.;Chen, S.-T.;Yip, P.-K.;Chen, T.-F.;Wu, C.-H.;Wen, M.-C.;Tseng, H.-H.;Chu, Y.-C.;Wang, C.-Y.;Tu, Pei Chong
    涂珮瓊
    貢獻者: 心理系
    關鍵詞: adult;aged;Alzheimer disease;amnesia;analysis of covariance;analysis of variance;article;controlled study;dementia;disease severity;education;human;major clinical study;neurologic examination;recall;recognition;semantics;Aged;Case-Control Studies;Dementia;Educational Status;Humans;Mental Recall;Neuropsychological Tests;Semantics;Severity of Illness Index
    日期: 2006-11
    上傳時間: 2015-07-21 15:34:45 (UTC+8)
    摘要: Background/Purpose: Although a deficit of semantic memory is evident in the dementia of the Alzheimer`s type (DAT), the underlying neuropsychologic mechanism remains controversial. Breakdown of the semantic network during the course of DAT and an inability to access semantic information have been postulated as possible explanations, but supporting data are limited, particularly in low-educated patients. This study examined semantic memory in low-educated patients with different degrees of dementia severity. Methods: In total, 197 adult subjects were recruited, including 165 DAT patients and 32 normal controls. Subjects were divided into four subgroups according to their dementia severity. All subjects completed an episodic memory task, the Six-Object Memory Test, and semantic memory tasks including the Object Naming Test, the Remote Memory Test and the Semantic Association of Verbal Fluency Test. One-way ANOVA and ANCOVA with a post hoc Scheffe`s procedure were used to evaluate differences between groups. Results: All patients, irrespective of the degree of dementia, showed impaired performance on the Six-Object Memory Test [F(4, 163)=69.95, p<0.0001 for immediate recall; F(4, 163)=41.34, p<0.0001 for delayed recall]. On the semantic memory tasks, patients with moderate to severe dementia showed impaired performances on the Object Naming Test [F(4, 180)=28.25, p<0.0001] and the Remote Memory Test [F(4, 167)=26.22, p<0.0001 for recall; F(4, 167)=34.80, p<0.0001 for recognition], while all patients performed defectively on the Semantic Association of Verbal Fluency Test [F(4, 194)=70.43, p<0.0001]. Conclusion: Our results thus partially support the hypotheses that a loss of semantic structure and an inability to access semantic knowledge occur in the pathogenesis of DAT. ©2006 Elsevier & Formosan Medical Association.
    關聯: Journal of the Formosan Medical Association, 105(11), 926-935
    資料類型: article
    DOI 連結: http://dx.doi.org/10.1016/S0929-6646(09)60178-9
    DOI: 10.1016/S0929-6646(09)60178-9
    顯示於類別:[心理學系] 期刊論文

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