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    Title: 促進成年海馬迴神經前驅細胞增殖的藥物篩選
    Promoting proliferation of adult hippocampal neural
    Authors: 魏志安
    Contributors: 賴桂珍
    魏志安
    Keywords: 海馬迴
    成年神經新生
    神經球
    神經前驅細胞
    hippocampus
    Neural progenitor cells
    neurospheres
    Adult neurogenesis
    Date: 2013
    Issue Date: 2015-07-13 11:14:31 (UTC+8)
    Abstract: 在成年的哺乳類動物大腦中有兩個區域,可以不斷的有新的神經細胞生成,一個位於大腦側腦室旁內側(Subventricular zone of anterior lateral ventricle ;SVZ),另一個位於海馬迴(hippocampus)內的齒狀迴(Subgran-
    ular zone of dentate gyrus ;SGZ) ,其中海馬迴是本論文主要探討的腦區。
    神經前驅細胞(Neural progenitor cells :NPC)因具有自我更新(self
    -renewal)、增殖(proliferative)、多能(multipotent)的能力以及遷移性(Migration),所以可利用海馬迴內生性的神經前驅細胞(NPC),促進其增殖以替代因損傷、老化或疾病而損失的神經細胞。神經前驅細胞經由細胞體外培養過程會形成神經球(Neurospheres),神經球和神經前驅細胞同樣具有自我更新以及可以分化成其他神經細胞的能力。
    本研究觀察到,對成年神經新生進行體外藥物的篩選中,化合物Chemical-X,有明顯的促進神經新生的能力。實驗中取健康成年雄性大鼠為實驗動物,分離出成年大鼠之海馬迴神經前驅細胞。用Chemical-X處理後,觀察神經球自我更新能力,以及再把新生成的神經球利用免疫螢光染色處理,瞭解神經前驅細胞經藥物處理後所新生成的細胞,是否仍維持在神經前驅細胞的狀態。進而評估藥物能否達到促進神經新生的目的。
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    Description: 碩士
    國立政治大學
    神經科學研究所
    100754002
    102
    Source URI: http://thesis.lib.nccu.edu.tw/record/#G0100754002
    Data Type: thesis
    Appears in Collections:[神經科學研究所] 學位論文

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