政大機構典藏-National Chengchi University Institutional Repository(NCCUR):Item 140.119/76020
English  |  正體中文  |  简体中文  |  Post-Print筆數 : 27 |  全文筆數/總筆數 : 113980/145005 (79%)
造訪人次 : 52018477      線上人數 : 738
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋


    請使用永久網址來引用或連結此文件: https://nccur.lib.nccu.edu.tw/handle/140.119/76020


    題名: Involvement of p53 R72P polymorphism in the association of MDM2-SNP309 with breast cancer
    作者: Leu, Jyh-Der;Wang, C.-Y.;Tsai, H.-Y.;Lin, I-F.;Chen, R.-C.;Lee, Y.-J.
    呂志得
    貢獻者: 神科所
    關鍵詞: arginine;proline;protein MDM2;protein p53;adult;aged;allele;amino acid substitution;article;Asian;breast cancer;breast carcinogenesis;cancer cell culture;cancer risk;controlled study;embryo;female;gene expression;gene frequency;genetic association;genetic variability;genotype;homozygosity;human;human cell;human tissue;major clinical study;male;priority journal;promoter region;single nucleotide polymorphism;Taiwan;Asian Continental Ancestry Group;Breast Neoplasms;Breast Neoplasms, Male;Female;Genetic Predisposition to Disease;Genotype;Humans;Male;Middle Aged;Polymorphism, Single Nucleotide;Proto-Oncogene Proteins c-mdm2;Reverse Transcriptase Polymerase Chain Reaction;Taiwan;Tumor Suppressor Protein p53
    日期: 2011-06
    上傳時間: 2015-06-22 14:53:13 (UTC+8)
    摘要: The allelic variant MDM2-SNP309 (T>G) has been suggested to influence cancer development, but the clinical correlation between the risk allele and breast cancer remains controversial. The genetic background and the ethnicity of selected subgroups may influence the power of these risk genotypes. In this study, we investigated whether MDM2-SNP309 is associated with p53 R72P genetic polymorphism for the risk of breast cancer development in Asian Taiwanese, which has not been well-studied in this regard. Two hundred and fifty-five patients and 324 cancer-free controls were included, and we found that the MDM2-SNP309 TG and GG genotypes displayed marginally increased risks of breast cancer (GG vs. TT: OR = 1.7, 95% CI = 0.93 to 3.09; TG+ TT vs. TT: OR = 1.57, 95% CI = 0.98 to 2.56) The breast cancer risk asso-ciated with MDM2-SNP309 was enhanced after stratification for the homozygous GG genotype at p53 codon 72 representing the Arg form of this genotype (GG vs. TT: OR = 3.7, 95% CI = 1.144 to 12.02; TG + GG vs. TT: OR = 2.7, 95% CI = 1.027 to 6.895). Also, the median age at diagnosis of patients with MDM2-SNP309 GG increased from 4 years earlier to 9 years earlier than TT patients after stratification for the GG geno-type at p53 codon 72. Moreover, the G-allele of MDM2-SNP309 exhibited a stronger capacity than the T-allele to drive the full-length P2 promoter of the MDM2 gene in several human cell lines, suggesting that the association between MDM2-SNP309 and breast cancer is likely multifactorial rather than due to inconsistent gene expression in different cancer sources. Copyright © 2011 Spandidos Publications Ltd. All rights reserved.
    關聯: Oncology Reports, 25(6), 1755-1763
    資料類型: article
    DOI 連結: http://dx.doi.org/10.3892/or.2011.1254
    DOI: 10.3892/or.2011.1254
    顯示於類別:[神經科學研究所] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    index.html0KbHTML21244檢視/開啟


    在政大典藏中所有的資料項目都受到原著作權保護.


    社群 sharing

    著作權政策宣告 Copyright Announcement
    1.本網站之數位內容為國立政治大學所收錄之機構典藏，無償提供學術研究與公眾教育等公益性使用，惟仍請適度，合理使用本網站之內容，以尊重著作權人之權益。商業上之利用，則請先取得著作權人之授權。
    The digital content of this website is part of National Chengchi University Institutional Repository. It provides free access to academic research and public education for non-commercial use. Please utilize it in a proper and reasonable manner and respect the rights of copyright owners. For commercial use, please obtain authorization from the copyright owner in advance.

    2.本網站之製作，已盡力防止侵害著作權人之權益，如仍發現本網站之數位內容有侵害著作權人權益情事者，請權利人通知本網站維護人員(nccur@nccu.edu.tw)，維護人員將立即採取移除該數位著作等補救措施。
    NCCU Institutional Repository is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff(nccur@nccu.edu.tw). We will remove the work from the repository and investigate your claim.
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋