政大機構典藏-National Chengchi University Institutional Repository(NCCUR):Item 140.119/75541
English  |  正體中文  |  简体中文  |  Post-Print筆數 : 27 |  Items with full text/Total items : 113648/144635 (79%)
Visitors : 51571533      Online Users : 852
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version


    Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/75541


    Title: Biomarker selection for medical diagnosis using the partial area under the ROC curve
    Authors: Hsu, M.-J.;Chang, Yuan-Chin Ivan;Hsueh, Huey-Miin
    張源俊;薛慧敏
    Contributors: 統計系
    Keywords: biological marker;algorithm;area under the curve;article;blood;breast disease;computer simulation;coronary artery disease;diagnosis;Duchenne muscular dystrophy;genetics;heterozygote detection;impedance;normal distribution;pathology;receiver operating characteristic;sensitivity and specificity;Algorithms;Area Under Curve;Biological Markers;Breast Diseases;Computer Simulation;Coronary Artery Disease;Diagnosis;Electric Impedance;Heterozygote Detection;Muscular Dystrophy;Duchenne;Normal Distribution;ROC Curve;Sensitivity and Specificity
    Date: 2014-01
    Issue Date: 2015-06-03 11:16:46 (UTC+8)
    Abstract: Background: A biomarker is usually used as a diagnostic or assessment tool in medical research. Finding an ideal biomarker is not easy and combining multiple biomarkers provides a promising alternative. Moreover, some biomarkers based on the optimal linear combination do not have enough discriminatory power. As a result, the aim of this study was to find the significant biomarkers based on the optimal linear combination maximizing the pAUC for assessment of the biomarkers. Methods. Under the binormality assumption we obtain the optimal linear combination of biomarkers maximizing the partial area under the receiver operating characteristic curve (pAUC). Related statistical tests are developed for assessment of a biomarker set and of an individual biomarker. Stepwise biomarker selections are introduced to identify those biomarkers of statistical significance. Results: The results of simulation study and three real examples, Duchenne Muscular Dystrophy disease, heart disease, and breast tissue example are used to show that our methods are most suitable biomarker selection for the data sets of a moderate number of biomarkers. Conclusions: Our proposed biomarker selection approaches can be used to find the significant biomarkers based on hypothesis testing. © 2014 Hsu et al.; licensee BioMed Central Ltd.
    Relation: BMC Research Notes, 7(1), 論文編號 25
    Data Type: article
    DOI link: http://dx.doi.org/10.1186/1756-0500-7-25
    DOI: 10.1186/1756-0500-7-25
    Appears in Collections:[Department of Statistics] Periodical Articles

    Files in This Item:

    File Description SizeFormat
    1-11.pdf595KbAdobe PDF2643View/Open


    All items in 政大典藏 are protected by copyright, with all rights reserved.


    社群 sharing

    著作權政策宣告 Copyright Announcement
    1.本網站之數位內容為國立政治大學所收錄之機構典藏，無償提供學術研究與公眾教育等公益性使用，惟仍請適度，合理使用本網站之內容，以尊重著作權人之權益。商業上之利用，則請先取得著作權人之授權。
    The digital content of this website is part of National Chengchi University Institutional Repository. It provides free access to academic research and public education for non-commercial use. Please utilize it in a proper and reasonable manner and respect the rights of copyright owners. For commercial use, please obtain authorization from the copyright owner in advance.

    2.本網站之製作，已盡力防止侵害著作權人之權益，如仍發現本網站之數位內容有侵害著作權人權益情事者，請權利人通知本網站維護人員(nccur@nccu.edu.tw)，維護人員將立即採取移除該數位著作等補救措施。
    NCCU Institutional Repository is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff(nccur@nccu.edu.tw). We will remove the work from the repository and investigate your claim.
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback