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    政大機構典藏 > 理學院 > 心理學系 > 期刊論文 >  Item 140.119/75234


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    題名: Hepatitis B virus genotypes: Clinical relevance and therapeutic implications
    作者: Lin, Chih-Lin
    林志陵
    Kao, J.-H.
    貢獻者: 心理系
    關鍵詞: adefovir dipivoxil;antivirus agent;entecavir;interferon;lamivudine;nucleoside derivative;nucleotide derivative;peginterferon;telbivudine;tenofovir disoproxil;article;cancer risk;drug efficacy;drug response;genetic association;genetic variability;genotype;geographic distribution;hepatitis B;Hepatitis B virus;high risk patient;human;immune response;liver cell carcinoma;low drug dose;molecular epidemiology;nonhuman;outcome assessment;prognosis;recurrent disease;risk assessment;seroconversion;virus genome;virus load;virus replication;virus virulence
    日期: 2013-06
    上傳時間: 2015-05-21 16:24:25 (UTC+8)
    摘要: At least ten hepatitis B virus (HBV) genotypes (A to J) with distinct geographic distributions have been recognized. HBV genotype is not only predictive of clinical outcome but also implicated in responsiveness to antiviral therapy, especially interferon-based regimens. HBV genotype-specific immunologic and virological pathogenesis may contribute to heterogeneous clinical outcomes in chronic hepatitis B patients. For example, patients with genotypes C and D infection have a lower rate of spontaneous HBeAg seroconversion. In addition, genotype C and D have a higher frequency of basal core promoter A1762T/G1764A mutation than genotype A and B. Genotypes C and D also carry a higher risk of cirrhosis and HCC development than genotype A and B. Therapeutically, genotype A and B patients have a better response to interferon-based therapy than genotypes C and D patients, but the response to nucleos(t)ide analogues is comparable across all HBV genotypes. In conclusion, genotyping of HBV can help practicing physicians identify chronic hepatitis B patients who are at risk of disease progression and optimize anti-viral therapy in clinical practice. © 2013 Springer Science+Business Media New York.
    關聯: Current Hepatitis Reports, 12(2), 124-132
    資料類型: article
    DOI 連結: http://dx.doi.org/10.1007/s11901-013-0166-6
    DOI: 10.1007/s11901-013-0166-6
    顯示於類別:[心理學系] 期刊論文

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