政大機構典藏-National Chengchi University Institutional Repository(NCCUR):Item 140.119/75234
English  |  正體中文  |  简体中文  |  Post-Print筆數 : 27 |  全文筆數/總筆數 : 112871/143842 (78%)
造訪人次 : 49946101      線上人數 : 632
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    政大機構典藏 > 理學院 > 心理學系 > 期刊論文 >  Item 140.119/75234


    請使用永久網址來引用或連結此文件: https://nccur.lib.nccu.edu.tw/handle/140.119/75234


    題名: Hepatitis B virus genotypes: Clinical relevance and therapeutic implications
    作者: Lin, Chih-Lin
    林志陵
    Kao, J.-H.
    貢獻者: 心理系
    關鍵詞: adefovir dipivoxil;antivirus agent;entecavir;interferon;lamivudine;nucleoside derivative;nucleotide derivative;peginterferon;telbivudine;tenofovir disoproxil;article;cancer risk;drug efficacy;drug response;genetic association;genetic variability;genotype;geographic distribution;hepatitis B;Hepatitis B virus;high risk patient;human;immune response;liver cell carcinoma;low drug dose;molecular epidemiology;nonhuman;outcome assessment;prognosis;recurrent disease;risk assessment;seroconversion;virus genome;virus load;virus replication;virus virulence
    日期: 2013-06
    上傳時間: 2015-05-21 16:24:25 (UTC+8)
    摘要: At least ten hepatitis B virus (HBV) genotypes (A to J) with distinct geographic distributions have been recognized. HBV genotype is not only predictive of clinical outcome but also implicated in responsiveness to antiviral therapy, especially interferon-based regimens. HBV genotype-specific immunologic and virological pathogenesis may contribute to heterogeneous clinical outcomes in chronic hepatitis B patients. For example, patients with genotypes C and D infection have a lower rate of spontaneous HBeAg seroconversion. In addition, genotype C and D have a higher frequency of basal core promoter A1762T/G1764A mutation than genotype A and B. Genotypes C and D also carry a higher risk of cirrhosis and HCC development than genotype A and B. Therapeutically, genotype A and B patients have a better response to interferon-based therapy than genotypes C and D patients, but the response to nucleos(t)ide analogues is comparable across all HBV genotypes. In conclusion, genotyping of HBV can help practicing physicians identify chronic hepatitis B patients who are at risk of disease progression and optimize anti-viral therapy in clinical practice. © 2013 Springer Science+Business Media New York.
    關聯: Current Hepatitis Reports, 12(2), 124-132
    資料類型: article
    DOI 連結: http://dx.doi.org/10.1007/s11901-013-0166-6
    DOI: 10.1007/s11901-013-0166-6
    顯示於類別:[心理學系] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    124-132.pdf200KbAdobe PDF2695檢視/開啟


    在政大典藏中所有的資料項目都受到原著作權保護.


    社群 sharing

    著作權政策宣告 Copyright Announcement
    1.本網站之數位內容為國立政治大學所收錄之機構典藏，無償提供學術研究與公眾教育等公益性使用，惟仍請適度，合理使用本網站之內容，以尊重著作權人之權益。商業上之利用，則請先取得著作權人之授權。
    The digital content of this website is part of National Chengchi University Institutional Repository. It provides free access to academic research and public education for non-commercial use. Please utilize it in a proper and reasonable manner and respect the rights of copyright owners. For commercial use, please obtain authorization from the copyright owner in advance.

    2.本網站之製作，已盡力防止侵害著作權人之權益，如仍發現本網站之數位內容有侵害著作權人權益情事者，請權利人通知本網站維護人員(nccur@nccu.edu.tw)，維護人員將立即採取移除該數位著作等補救措施。
    NCCU Institutional Repository is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff(nccur@nccu.edu.tw). We will remove the work from the repository and investigate your claim.
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋