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政大機構典藏 > 商學院 > 統計學系 > 期刊論文 > Item 140.119/74375

Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/74375

Title:	A Generalized Additive Model For Microarray Gene Expression Data Analysis
Authors:	Hsueh, Huey-miin;Tsai, Chen-An;Chen, James J. 薛慧敏
Contributors:	統計系
Date:	2004
Issue Date:	2015-04-07 17:02:33 (UTC+8)
Abstract:	Microarray technology allows the measurement of expression levels of a large number of genes simultaneously. There are inherent biases in microarray data generated from an experiment. Various statistical methods have been proposed for data normalization and data analysis. This paper proposes a generalized additive model for the analysis of gene expression data. This model consists of two sub-models: a non-linear model and a linear model. We propose a two-step normalization algorithm to fit the two sub-models sequentially. The first step involves a non-parametric regression using lowess fits to adjust for non-linear systematic biases. The second step uses a linear ANOVA model to estimate the remaining effects including the interaction effect of genes and treatments, the effect of interest in a study. The proposed model is a generalization of the ANOVA model for microarray data analysis. We show correspondences between the lowess fit and the ANOVA model methods. The normalization procedure does not assume the majority of genes do not change their expression levels, and neither does it assume two channel intensities from the same spot are independent. The procedure can be applied to either one channel or two channel data from the experiments with multiple treatments or multiple nuisance factors. Two toxicogenomic experiment data sets and a simulated data set are used to contrast the proposed method with the commonly known lowess fit and ANOVA methods.
Relation:	Journal of Biopharmaceutical Statistics - J BIOPHARM STAT , vol. 14, no. 3, pp. 553-573
Data Type:	article
DOI 連結:	http://dx.doi.org/10.1081/BIP-200025648
DOI:	10.1081/BIP-200025648
Appears in Collections:	[統計學系] 期刊論文

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