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    題名: Subordination stress alters alternative splicing of the Slo gene in tree shrew adrenals
    作者: 賴桂珍
    David P McCobb;Yuko Hara;Lai,Guey-Jen;Sahar F Mahmoud;Gabriele Flügge
    貢獻者: 神科所
    關鍵詞: Potassium channels;BK channels;Slo;HPA axis;Psychosocial stress;Alternative splicing;Steroids
    日期: 2003.01
    上傳時間: 2014-09-23 12:26:25 (UTC+8)
    摘要: It was previously hypothesized that stress hormones regulate the alternative splicing of Slo potassium channels, thereby tuning the intrinsic excitability of adrenal chromaffin cells. Male tree shrews subjected to chronic stress by exposure to a dominant male develop robust symptoms with parallels to human depression. We report here that adrenals from males subjected to 4–6 weeks of subordination have a significantly smaller proportion of Slo transcripts with the optional STREX exon (STRess-axis regulated EXon) than unstressed male adrenals. Female adrenals (unstressed) had even lower levels than stressed males. These data suggest both behavioral regulation and sexual dimorphism in ion channel structure. We hypothesize that chromaffin cell excitability and sympathoadrenal function will be altered, and speculate that this may favor passive coping responses in subordinate males and females.
    關聯: Hormones and Behavior,43(1),180-186
    資料類型: article
    顯示於類別:[神經科學研究所] 期刊論文

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