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政大典藏 > College of Science > Department of Psychology > Periodical Articles > Item 140.119/67230

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Title:	Place conditioning and neurochemical responses elicited by the aftereffect of acute stressor exposure involving an elevated stand.
Authors:	Shen,YL;Chen,JC;Liao,RM
Contributors:	心理系
Date:	2011.01
Issue Date:	2014-07-02 16:13:44 (UTC+8)
Abstract:	Acute exposure to an elevated stand has been used as an inescapable mild stressor for rats. The present study examined the effects of this stressor using a place conditioning behavioral test and neurochemical assays of dopamine and its metabolite, 3,4-dihydroxyphenylacetic acid (DOPAC), in the medial prefrontal cortex and nucleus accumbens. The behavioral data showed that a conditioned place preference was formed as an aftereffect of the elevated stand stressor. In a separate experiment, neurochemical assay showed an immediate increase of dopamine in the nucleus accumbens after 30min exposure to the elevated stand stressor. In addition, the DOPAC content in the nucleus accumbens was significantly increased at 30min after this stressor. No significant change in dopamine or DOPAC levels in the medial prefrontal cortex was detected for up to 60min after stressor manipulation. These results suggest that an increase in dopamine activity in the nucleus accumbens is involved in the development of conditioned place preference elicited by the aftereffects of the elevated stand stressor.
Relation:	Neuroscience Letters,504,156-159
Data Type:	article
DOI link:	http://dx.doi.org/10.1016/j.neulet.2011.09.022
DOI:	10.1016/j.neulet.2011.09.022
Appears in Collections:	[Department of Psychology] Periodical Articles

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