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    题名: Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain
    作者: YR Lin;HH Chen;YC Lin;CH Ko;MH Chan
    詹銘煥
    贡献者: 神科所
    日期: 2009.1
    上传时间: 2014-04-09 17:43:43 (UTC+8)
    摘要: The antinociceptive effects of honokiol and magnolol, two major bioactive constituents of the bark of Magnolia officinalis, were investigated on animal paw licking responses and thermal hyperalgesia induced by glutamate receptor agonists including glutamate, N-methyl-D-aspartate (NMDA), and metabotropic glutamate 5 receptor (mGluR5) activator (RS)-2-chloro-5-hydroxyphenylglycine (CHPG), as well as inflammatory mediators such as substance P and prostaglandin E2 (PGE2) in mice. The actions of honokiol and magnolol on glutamate-induced c-Fos expression in the spinal cord dorsal horn were also examined. Our data showed that honokiol and magnolol blocked glutamate-, substance P- and PGE2-induced inflammatory pain with similar potency and efficacy. Consistently, honokiol and magnolol significantly decreased glutamate-induced c-Fos protein expression in superficial (I-II) laminae of the L4-L5 lumbar dorsal horn. However, honokiol was more selective than magnolol for inhibition of NMDA-induced licking behavioral and thermal hyperalgesia. In contrast, magnolol was more potent to block CHPG-mediated thermal hyperalgesia. These results demonstrate that honokiol and magnolol effectively decreased the inflammatory pain. Furthermore, their different potency on inhibition of nociception provoked by NMDA receptor and mGluR5 activation should be considered.
    關聯: Journal of Biomedical Science,16(1), 94
    数据类型: article
    DOI 連結: http://dx.doi.org/10.1186/1423-0127-16-94
    DOI: 10.1186/1423-0127-16-94
    显示于类别:[神經科學研究所] 期刊論文

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