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    题名: Toluene exposure during brain growth spurt and adolescence produces differential effects on N-methyl-d-aspartate receptor-mediated currents in rat hippocampus
    作者: Chen, Hwei-Hsien;Lin, Yi-Ruu;Chan, Ming-Huan
    詹銘煥
    贡献者: 神科所
    关键词: Solvent;NMDA receptor;Neonatal;Adolescent;EPSCs
    日期: 2011.09
    上传时间: 2014-04-09 17:18:07 (UTC+8)
    摘要: Toluene, an industrial organic solvent, is voluntarily inhaled as drug of abuse. Because inhibition of N-methyl-d-aspartate (NMDA) receptors is one of the possible mechanisms underlying developmental neurotoxicity of toluene, the purpose of the present study was to examine the effects of toluene exposure during two major neurodevelopmental stages, brain growth spurt and adolescence, on NMDA receptor-mediated current. Rats were administered with toluene (500 mg/kg, i.p.) or corn oil daily over postnatal days (PN) 4–9 (brain growth spurt) or PN 21–26 (early adolescence). Intracellular electrophysiological recordings employing in CA1 pyramidal neurons in the hippocampal slices were performed during PN 30–38. Toluene exposure during brain growth spurt enhanced NMDA receptor-mediated excitatory postsynaptic currents (EPSCs) by electrical stimulation, but impaired the paired-pulse facilitation and NMDA response by exogenous application of NMDA. Toluene exposure during adolescence resulted in an increase in NMDA receptor-mediated EPSCs and a decrease in exogenous NMDA-induced currents, while lack of any effect on paired-pulse facilitation. These findings suggest that toluene exposure during brain growth spurt and adolescence might result in an increase in synaptic NMDA receptor responsiveness and a decrease in extrasynaptic NMDA receptor responsiveness, while only toluene exposure during brain growth spurt can produce presynaptic modulation in CA1 pyramidal neurons. The functional changes in NMDA receptor-mediated transmission underlying developmental toluene exposure may lead to the neurobehavioral disturbances.
    關聯: Toxicology Letters,205(3), 336-340
    資料來源: http://dx.doi.org/10.1016/j.toxlet.2011.06.026
    数据类型: article
    显示于类别:[神經科學研究所] 期刊論文

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