政大機構典藏-National Chengchi University Institutional Repository(NCCUR):Item 140.119/61290
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    Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/61290


    Title: 非線性時間序列分析沮喪引起的心臟疾病
    Authors: 蕭又新
    Contributors: 國立政治大學應用物理研究所
    Shiau,Yuo-Hsien
    Keywords: Heart;Time series;Homeostasis;Mathematical models;Diagnosis
    Date: 2009
    Issue Date: 2013-10-11 12:05:47 (UTC+8)
    Abstract: 「心臟疾病」是我們耳熟能詳的話題，心臟的重要性也早已在基礎的教育課程就
    深植於我們心中。根據衛生署於九十一年的國人十大死因統計【1】，因心臟疾病
    死亡人數為11441 人，高居第三位，不僅如此，二十年來心臟疾病一直都在十大
    死因「榜上有名」，總是佔據著第三、四位，並有向上攀升的趨勢，這樣的訊息
    顯示出若心臟疾病的問題不盡快獲得改善，將繼續主宰著我們生命的健康與否。
    除此之外，近年來由研究學者提出憂鬱沮喪的心情會導致心臟疾病已引起廣泛的
    注意與討論，例如在「第三屆國際心臟血管病大會」發表的一項美日合作研究結
    果顯示，憂鬱沮喪的心情可能也是促使心血管病患發作的隱形殺手（如圖一）。
    反之，當病人接受冠狀動脈繞道手術時，醫師在手術前多半會告訴病人與家屬，
    有些病人在手術之後會產生抑鬱症狀，但若想知道哪些人會有症狀，嚴重情形如
    何，就很少有人能夠回答了，因為相關的研究並不多，不是研究中病人取樣不夠
    多，就是難以判斷心臟疾病與抑鬱症乃至於其他致病因子之間的關聯。此外，研
    究人員亦發現在手術前後具有中度到重度憂鬱的病患，或者輕到重度的憂鬱情形
    持續達六個月以上，病患的死亡機率比沒有憂鬱症狀的病患高了兩倍，而像這樣
    從生理影響心理及從心理影響生理反應已成為新興的研究主題。
    Analyzing heart rate variability from electrocardiographic recordings has been an important method for
    assessing cardiovascular autonomic regulation. Researchers have conducted extensive analyses on normal as
    well as pathological hearts, however, it is still unclear whether increasing or decreasing the complexity of
    heart rate variability is a characteristic of healthy systems. In this study, we find the existence of wellharmonized
    homeostasis in heart rate fluctuations, in particular, the evidence is verified among different
    individuals including healthy subjects, ICU patients, and one child with brainstem dysfunction. The
    methodology we used is composed of two parts, in which one is the consideration of reduction of
    cardiorespiratory fluctuations inherited in the original R–R intervals and the other is based upon the concept
    of nonlinear dynamics to construct the low-dimensional trajectory in the angle plot. The cross-correlation
    measure between the theoretical angle map and the numerically derived angle trajectory is used to separate
    recovery (0.73±0.13) from deterioration (0.25±0.08) of ICU patients. In addition, a simple physiologic
    (deterministic) model of the interaction between the cardiovascular system and baroreceptor control of
    arterial pressure is used to explain why homeostasis can exist in heart rate fluctuations. Our study provides a
    potential link between the clinical data and circulatory system.
    Relation: 執行期間：9708 -9812
    Data Type: report
    Appears in Collections:[Graduate Institute of Applied Physics] NSC Projects

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