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政大機構典藏 > 理學院 > 心理學系 > 會議論文 > Item 140.119/58744

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Title:	Licking performance on a choice procedure under dopamine receptor blockade in the rat
Authors:	廖瑞銘 Wang, S. H.
Contributors:	國立政治大學心理學系
Date:	2000
Issue Date:	2013-07-11 13:54:12 (UTC+8)
Publisher:	Society for neuroscience, Society for neuroscience
Abstract:	Although interference with the dopamine (DA) systems has been shown to impair instrumental behavior, it may have a little or no effect on the basic processes of motivation (Salamone, 1992). The present study was designed to directly examine the effects of DA receptor antagonists on licking in a choice situation. The food-deprived rats were trained to lick for the solution from either a high-positioned 20% sucrose or the low-positioned 15% sucrose. After 10 to 14 sessions of training, the subject significantly preferred to consume the high-positioned 20% sucrose solution. Drug treatment was conducted by IP injection of SCH23390 (0.05, 0.1, 0.2 mg/kg), raclopride (0.1, 0.2 mg/kg), or haloperidol (0.05, 0.1 mg/kg). While the licking of high-positioned 20% sucrose was dose-related suppressed by all three drugs, the concurrent consumption of the low-positioned 15% sucrose was significantly enhanced. However, a more experience of licking on the low-positioned liquid was required for the subject to produce such a behavioral reallocation under raclopride and haloperidol treatments, but not under SCH23390. These results indicate that the motivational processing can be adjusted to counteract behavioral changes under DA receptor blockade.
Data Type:	conference
Appears in Collections:	[心理學系] 會議論文

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